Results 141 to 150 of about 3,459,561 (335)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists
International Journal of Endocrinology, 2012 Aldosterone, a specific mineralocorticoid receptor (MR) agonist and a key player in the development of hypertension, is synthesized as a final product of renin-angiotensin-aldosterone system.
Keiichi Ikeda +4 more
doaj +1 more source
Kaposiform hemangioendothelioma: Diagnosis and treatment
Pediatric Investigation, EarlyView.Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian +5 more
wiley +1 more source
Management of renin-angiotensin system inhibitors prior to major surgery: insights from the STOP-or-NOT trial. [PDF]
Strong recommendations on how to manage renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, before surgery are lacking because of a lack of evidence, which is mostly limited to data ...
Gayat, Etienne, Legrand, Matthieu
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Mechanisms for worse prognosis after myocardial infarction in low socioeconomic status are unclear. We therefore investigated the association between socioeconomic status and discontinuation of evidence‐based secondary prevention drug ...
Joel Ohm +5 more
doaj +1 more source
Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules. [PDF]
Bioorg Med Chem, 2020 Ramya K +4 more
europepmc +1 more source
VIEW, EarlyView.The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian +6 more
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews +3 more
wiley +1 more source
Theoretical design of new indole-3-carboxamide derivatives as renin inhibitors
, 2015 Renin inhibitors pertain to a new generation class of antihypertensive agents. There are only a few studies on the computational modeling of such class of compounds and only one available drug in the market used as renin inhibitor for the treatment of ...
Cunha, Elaine F. F. da +3 more
core +1 more source