Results 151 to 160 of about 3,459,561 (335)

Piperidine renin inhibitors: from leads to drug candidates

, 2001
Non-peptidomimetic renin inhibitors of the pipersine type represent the a novel structural class of compounds free of the drawbacks seen with peptidomimetic compounds so far.
Hirth, G., Gueller, R., Scalone, M., Valdenaire, O., Lave, T., Luft, F.C., Mueller, D.N., Reichel, A., Wilhelm, M., Zell, R., Zell, M., Mueller, M., Guenzi, A., Kansy, M., Vieira, E., Treiber, H., Fischli, W., Hartung, T., Wostl, W., Foricher, J., Klinkhammer, U., Oefner, C.H., Lohri, B., Breu, V., Funk, C.H., Montavon, F., Schleimer, M., Bur, D., D'Arcy, A., Jenny, C.H., Grueninger, F., Schmid, R., Bohner-Lang, V., Mervaala, E.M., Clozel, J.P., Sanwald-Ducray, P., Waldmeier, P., Doebeli, H., Coassolo, P.H., Bittner, B., Qiu, C., Maerki, H.P., Giller, T., Binggeli, A., Wiegand-Chou, R., Treiber, A.   +45 more
core   +1 more source

Renin Inhibitor in Soybean

, 2011
Renin-angiotensin-aldosterone system (RAS) is the most important blood pressure control system in animals (Fig. 1). Renin [EC 3. 4. 23. 15] is a highly specific aspartic proteinase that is mainly synthesized by juxtaglomerular (JG) cells in the kidney.
Saori Takahashi, Takeshi Gotoh, Kazuyuki Hori   +2 more
openaire   +2 more sources

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Highly potent and specific inhibitors of human renin

, 1987
We have designed and synthesized a series of small peptides containing a perfluoroalkyl ketone group at the C-terminal position of the angiotensin I sequence as inhibitors of human renin.
Rempel, Cheryl A., Cheryl A. Rempel, Sham, Hing L., Herman Stein, Cohen, Jerome, Stein, Herman, Plattner, Jacob J., Hing L. Sham, Jacob J. Plattner, Jerome Cohen   +9 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Emerging drug combinations to optimize renovascular protection and blood pressure goals

International Journal of Nephrology and Renovascular Disease, 2012
Carlos Escobar1, Rocio Echarri2, Vivencio Barrios31Department of Cardiology, Hospital Infanta Sofía, Madrid, Spain; 2Department of Nephrology, Hospital Infanta Sofía, Madrid, Spain; 3Department of Cardiology, Hospital Ramó
Escobar C, Echarri R, Barrios V
doaj  

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

How should anti-hypertensive medications be adjusted before screening for primary aldosteronism?

Journal of the Formosan Medical Association
Anti-hypertensive medications may affect plasma renin activity and/or plasma aldosterone concentration, misleading the interpretation of the aldosterone-to-renin ratio when screening for primary aldosteronism. The Task Force of Taiwan PA recommends that,
Jin-Ying Lu, Yi-Yao Chang, Ting-Wei Lee, Ming-Hsien Wu, Zheng-Wei Chen, Yen-Ta Huang, Tai-Shuan Lai, Leay Kiaw Er, Yen-Hung Lin, Vin-Cent Wu, Hao-Min Cheng, Hsien-Li Kao, Charles Jia-Yin Hou, Kwan-Dun Wu, Szu-Tah Chen, Feng-Hsuan Liu   +15 more
doaj   +1 more source

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source