Results 171 to 180 of about 756,250 (282)

Aldosterone Synthase Inhibition in Diabetes and Cardiorenal Metabolic Disease. [PDF]

J Diabetes
Bloomgarden Z.
europepmc   +1 more source

What do we know about nephrotoxicity of NSAIDs in horses?

Equine Veterinary Education, EarlyView.
C. Di Donato, G. van Galen
wiley   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Subclinical primary aldosteronism: toward a conceptual framework linking primary aldosteronism and low-renin hypertension. [PDF]

Front Endocrinol (Lausanne)
Park CH.
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Lipid metabolism-related inflammatory indices and diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study. [PDF]

Front Endocrinol (Lausanne)
Liu J, Tian X, Xu M, Xiao Y, Wei S, Pan X, Shi Y, Duan H, Zhang Y, Wei J.   +9 more
europepmc   +1 more source

Renin-angiotensin system inhibiting drugs and the development of direct renin inhibitors: Does cutting off the "head" achieve the goals of renin-angiotensin inhibition?

This mini-review seeks to examine the molecular nature of renin-angiotensin system inhibitors and also the way in which their pharmacology relates to clinical effects.
Magas, Mark
core  

Targeting pepsin provides superior protection to acid suppression in reflux‐associated airway inflammation and lung dysfunction

Experimental Physiology, EarlyView.
Abstract Gastro‐oesophageal reflux disease is a prevalent condition associated with extra‐oesophageal manifestations, such as pulmonary inflammation. Pepsin, an essential gastric enzyme, has been implicated in pulmonary complications owing to its inflammatory effects.
Thiago Meneses Araújo Leite Sales, Humberto Barbosa da Costa Filho, Kalinne Kelly Lima Gadelha, Kerolayne de Melo Nogueira, Álvaro Xavier Franco, Carlos Eduardo da Silva Monteiro, Maria Klayre Araújo de Sousa, Monalisa Cássias Souza, Isabele de Sá Silveira Melo, Lucas Antonio Duarte Nicolau, Marco Antonio de Freitas Clementino, Pedro Jorge Caldas Magalhães, Alexandre Havt, Pedro Marcos Gomes Soares, Daniel Sifrim, Marcellus Henrique Loiola Ponte de Souza   +15 more
wiley   +1 more source

Cerebral blood flow in conscious rats and implications for therapeutic interventions

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans, Courtney R. Brighouse, Jack T. Sloan, Fiona D. McBryde   +3 more
wiley   +1 more source