Results 191 to 200 of about 756,250 (282)

Mechanisms of haemoglobin mass expansion following heat stress

The Journal of Physiology, EarlyView.
Abstract figure legend Theorised mechanisms of heat stress‐induced erythropoiesis which may facilitate the expansion of haemoglobin mass. A, acute: heat stress‐induced renal ischaemia. Redistribution of blood flow away from the kidneys to facilitate thermoregulation during heat stress could reduce renal oxygen delivery, subsequently lowering renal PO2${
Elliott J. Jenkins, Brittany A. Edgett, Michael G. Hughes, Joshua C. Tremblay, Mike Stembridge   +4 more
wiley   +1 more source

The Impact of Renin-Angiotensin-Aldosterone System Inhibitors in IgA Nephropathy: A Meta-Analysis of Randomized Controlled Trials. [PDF]

Clin J Am Soc Nephrol
Rastogi A, Sarkar M, Kawai K, Munoz G, Simon L, Hwang M, Khalid M, Rhee CM.   +7 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Effects of heart failure pharmacotherapy on natriuresis and diuresis: A narrative review. [PDF]

Heart Fail Rev
Jankowiak B, Ponikowski P, Biegus J.
europepmc   +1 more source

Augmenting erythropoiesis using recombinant human erythropoietin at sea level blunts the high altitude induced increase in erythropoiesis

The Journal of Physiology, EarlyView.
Abstract figure legend Pharmacologically augmenting erythropoiesis with rEPO at sea level blunts the high altitude induced erythropoiesis. Abstract Erythropoiesis increases with high altitude (HA) acclimatization. Recombinant human erythropoietin (rEPO) induces erythropoiesis.
Roy M. Salgado, Thomas A. Mayer, Gabrielle E. W. Giersch, Billie K. Alba, David E. Barney Jr, Aaron R. Caldwell, Nisha Charkoudian, Brandon M. Roberts, Afton D. Seeley, K. Riley Connor, Andrew M. Greenfield, Adam J. Luippold, Mark L. Plamper, Jermaine A. Ward, Shauna M. Ward, Benjamin J. Ryan   +15 more
wiley   +1 more source

Deconstruction of Aspartic Protease Inhibitors Enables Fragment-Based Discovery of Plasmepsin V Inhibitors. [PDF]

ChemMedChem
Skvorcova M, Ruduša L, Zelencova-Gopejenko D, Jirgensons A, Bobrovs R.   +4 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Renal diseases and blood pressure dysregulation in acute care: Pathophysiology, clinical patterns. [PDF]

World J Nephrol
Su YJ.
europepmc   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source