Results 181 to 190 of about 756,250 (282)

Renin-angiotensin system inhibitors and immunotherapy outcomes in lung cancer: a systematic review and meta-analysis with complementary transcriptomic analyses. [PDF]

Front Immunol
Li Q, Min X, Bai J, Liu X, Ye C.
europepmc   +1 more source

Effects of reducing sedentary behaviour on heart rate variability and cardio‐metabolic biomarkers in desk workers with untreated high blood pressure

Experimental Physiology, EarlyView.
Abstract Lower sedentary behaviour (SB) has been associated with reduced cardiovascular disease and mortality. Yet, few trials have evaluated cardiovascular mechanisms of benefit. We examined the effects of a SB reduction intervention on heart rate variability (HRV) and cardio‐metabolic biomarkers.
Abdullah Bandar Alansare, Matthew F. Muldoon, Subashan Perera, Kimberly A. Huber, Molly B. Conroy, John M. Jakicic, Bethany Barone Gibbs   +6 more
wiley   +1 more source

Clinical Significance of Cardio-Ankle Vascular Index in Stage A/B Heart Failure Patients With Type 2 Diabetes Mellitus. [PDF]

J Clin Med Res
Hitsumoto T.
europepmc   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

Mechanisms for Mineralocorticoid-Driven Age-Related Hypertension: Potential Therapeutic Role of Mineralocorticoid Receptor Antagonists and Aldosterone Synthase Inhibitors. [PDF]

Circ Res
Golec S, Vaidya A, Pitt B, Jaffe IZ.
europepmc   +1 more source

Early‐stage 2K1C renovascular hypertension does not increase global MHC‐II or F4/80 abundance in the non‐clipped kidney but reveals focal F4/80+ induction

Experimental Physiology, EarlyView.
Abstract The two‐kidney, one‐clip (2K1C) model produces renovascular hypertension. The effects on the clipped kidney (CK) are well described, while the non‐clipped kidney (NCK) is used as a model to evaluate the effects of high blood pressure. Although most of these effects have been described at later stages of 2K1C hypertension, it remains unclear ...
Pilar Cárdenas, Allison C. León, Juan Castillo‐Geraldo, Catalina Cid‐Salinas, Javiera Saez, Stefanny Figueroa, Javier Reyes, Emma Rosenkoetter, Suarybell Guzmán Román, Carmen De Miguel, Cristián A. Amador, Alexis A Gonzalez   +11 more
wiley   +1 more source

Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension. [PDF]

Life (Basel)
Pradhan A, Bhandari M, Singh A, Vishwakarma P, Mahajan K, Perrone MA, Batta A.   +6 more
europepmc   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source