PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer. [PDF]
PLoS ONE, 2017 Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven
Chandini Thirukkumaran +7 more
doaj +1 more source
Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus. [PDF]
PLoS ONE, 2017 Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells.
Xing Zhao +5 more
doaj +1 more source
Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]
, 2017 Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K +6 more
core +2 more sources
Mortality associated with avian reovirus infection in a free-living magpie (Pica pica) in Great Britain [PDF]
, 2015 Avian reoviruses (ARVs) cause a range of disease presentations in domestic, captive and free-living bird species. ARVs have been reported as a cause of significant disease and mortality in free-living corvid species in North America and continental ...
Cunningham, AA +9 more
core +1 more source
Bacteria and bacterial envelope components enhance mammalian reovirus thermostability. [PDF]
PLoS Pathogens, 2017 Enteric viruses encounter diverse environments as they migrate through the gastrointestinal tract to infect their hosts. The interaction of eukaryotic viruses with members of the host microbiota can greatly impact various aspects of virus biology ...
Angela K Berger +3 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been ...
Victoria Jennings +19 more
doaj +1 more source
Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]
, 2017 Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T +7 more
core +2 more sources
The role of cellular adhesion molecules in virus attachment and entry [PDF]
, 2015 As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core +1 more source
Frontiers in Oncology, 2014 The development of wild-type, unmodified Type 3 Dearing (T3D) strain reovirus as an anticancer agent has currently expanded to 32 clinical trials (both completed and ongoing) involving reovirus in the treatment of cancer.
Jun eGong, Monica Mirela Mita
doaj +1 more source
Combination therapy with reovirus and anti-PD-1 blockade controls tumor growth through innate and adaptive immune responses. [PDF]
, 2016 Oncolytic reovirus can be delivered both systemically and intratumorally, in both pre-clinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and anti-tumor activity is directly ...
Coffey, M +12 more
core +1 more source