Results 21 to 30 of about 27,637 (210)
Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]
, 2011 Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
AA Van Dijk +91 more
core +4 more sources
Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]
, 2018 Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B. +5 more
core +2 more sources
Mutagenic specificity in reovirus [PDF]
Journal of Virology, 1979 Mutagenic specificity in response to chemical mutagens has been observed with certain temperature-sensitive mutants of reovirus type 3. One mutant induced by nitrous acid reverted specifically with nitrous acid. Three nitrosoguanidine-induced mutants reverted after nitrous acid treatment.
U R, Ray, B N, Fields
openaire +2 more sources
Noncoding RNA Profile in Reovirus Treated KRAS-Mutated Colorectal Cancer Patients
Diseases, 2023 Purpose: To investigate the alterations in the expression of noncoding, micro, and small RNA expression during treatment with oncolytic reovirus in KRAS-mutated colorectal cancer. Methods: Oncolytic reovirus treatment was administered in phase 1 clinical
Rafael Saperstein +2 more
doaj +1 more source
Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models [PDF]
, 2016 Background: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop.
Campion, Ciorsdan A. +2 more
core +1 more source
Interferon-lambda: A potent regulator of intestinal viral infections [PDF]
, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core +3 more sources
Glycan Engagement Dictates Hydrocephalus Induction by Serotype 1 Reovirus
mBio, 2015 Receptors expressed on the host cell surface adhere viruses to target cells and serve as determinants of viral tropism. Several viruses bind cell surface glycans to facilitate entry, but the contribution of specific glycan moieties to viral disease is ...
Jennifer Stencel-Baerenwald +8 more
doaj +1 more source
A putative ATPase mediates RNA transcription and capping in a dsRNA virus. [PDF]
, 2015 mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9-3.1 Å) cryo-electron microscopy structures ...
Jiang, Jiansen +3 more
core +1 more source
Molecular Therapy: Oncolytics, 2019 Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combination ...
Masaya Igase +8 more
doaj +1 more source
Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.
PLoS Pathogens, 2020 Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and ...
Pavithra Aravamudhan +6 more
doaj +1 more source