Results 31 to 40 of about 27,637 (210)
Measles virus causes immunogenic cell death in human melanoma [PDF]
, 2011 Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn +14 more
core +1 more source
Molecular Therapy: Oncolytics, 2020 Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the ...
Martin McLaughlin +11 more
doaj +1 more source
Reovirus Receptors and Pathogenesis [PDF]
Journal of Virology, 2003 Mammalian reoviruses are nonenveloped viruses that contain a segmented double-stranded RNA genome. Most mammalian species, including humans, serve as hosts for reovirus infection, but reovirus-induced disease is restricted to the very young (reviewed in reference [61][1]).
J Craig, Forrest, Terence S, Dermody
openaire +2 more sources
Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling. [PDF]
PLoS ONE, 2018 Reovirus infection induces dramatic changes in host mRNA expression. We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a ...
Liang Guo +5 more
doaj +1 more source
CONGENITAL INFECTIONS WITH REOVIRUS [PDF]
The Journal of Experimental Medicine, 1966 Congenital reovirus, type 2 infections were produced after intraperitoneal inoculations of brood mothers on the 1st, 3rd, 6th, 10th, and 15th day of gestation. The offspring presented with a varied syndrome. About a quarter of a total of over 200 mice showed symptoms within the first 14 days of life; namely, lassitude, retarded growth, and roughening ...
A, Hahimi +3 more
openaire +2 more sources
Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.
PLoS Pathogens, 2008 Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection ...
Pranav Danthi +4 more
doaj +1 more source
Cancer Cell International, 2021 Background and aims Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems.
Seyed-Mahmood Seyed-Khorrami +3 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is likely that oncolytic viruses will be more effective when used in combination with other therapies.
Simon Gebremeskel +6 more
doaj +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles
mBio, 2021 The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee +8 more
doaj +1 more source