Results 81 to 90 of about 27,637 (210)

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

BMC Cancer, 2011
Background Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in combination with other modalities ...
Prestwich Robin, Melcher Alan, Vile Richard, Relph Kate L, Kottke Timothy, Boxall Angela, Simpson Guy R, Heinemann Lucy, Harrington Kevin J, Morgan Richard, Pandha Hardev S   +10 more
doaj   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche‐Specific Adaptation

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT The intestinal immune system is constantly challenged to distinguish between innocuous dietary antigens, commensal microbiota and intestinal self‐antigens (self‐Ags) versus harmful pathogens and malignant cells. It resides in the intestinal wall itself, Peyer's patches (PPs) and the draining lymph nodes (LNs).
Yixuan D. Zhou, Macy R. Komnick, Daria Esterházy   +2 more
wiley   +1 more source

Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells

Virology Journal, 2005
Background Mammalian reoviruses naturally infect their hosts through the enteric and respiratory tracts. During enteric infections, proteolysis of the reovirus outer capsid protein σ3 is mediated by pancreatic serine proteases. In contrast, the proteases
Schiff Leslie A, Golden Joseph W
doaj   +1 more source

Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. [PDF]

PLoS Pathogens, 2015
Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases ...
Joshua D Doyle, Jennifer E Stencel-Baerenwald, Courtney A Copeland, Jillian P Rhoads, Judy J Brown, Kelli L Boyd, James B Atkinson, Terence S Dermody   +7 more
doaj   +1 more source

BRAF- and MEK-targeted small molecule inhibitors exert enhanced antimelanoma effects in combination with oncolytic reovirus through ER stress [PDF]

, 2015
Reovirus type 3 (Dearing) (RT3D) infection is selective for cells harboring a mutated/activated RAS pathway. Therefore, in a panel of melanoma cell lines (including RAS mutant, BRAF mutant and RAS/BRAF wild-type), we assessed therapeutic combinations ...
Aadil A Khan, Adel Jebar, Alan Melcher, Bollag, Boyce, Carew, Chandra, Chapman, Comins, da Rocha Dias, David Mansfield, Davies, Dhomen, Eleni Karapanagiotou, Fiona Errington-Mais, Flaherty, Flaherty, Galanis, Gollamudi, Grainne McEntee, Hardev Pandha, Heidorn, Heinemann, Hu, Jiang, Jiang, Joan Kyula, Karapanagiotou, Kelly, Kevin J Harrington, Kyula, Lolkema, Malin Pedersen, Mandarà, Marciniak, Martin McLaughlin, Matt Coffey, McArthur, Michelle Wilkinson, Pandha, Richard Marais, Richard Vile, Roulstone, Sei, Sosman, Strong, Tabas, Tay, Tsaytler, Twigger, Victoria Roulstone, Vidal, Young   +52 more
core   +1 more source

A Review of the Control of Coccidiosis in Poultry Using Natural Additives, Focusing on Gut Health and Immunity

Advances in Agriculture, Volume 2026, Issue 1, 2026.
Coccidiosis is one of the most common diseases in the poultry industry worldwide (especially in broilers aged 3–6 weeks), causing significant economic losses to poultry farmers and governments every year. Conventional methods (anticoccidial chemical compounds) for the coccidiosis debarment and control always present challenges and disadvantages, such ...
Fatemeh Aziz-Aliabadi, Hadi Noruzi, Zeyad Kamal Imari, Lee Seong Wei   +3 more
wiley   +1 more source

Incidência de reovírus em algumas cidades do Rio Grande do Sul

Revista do Instituto de Medicina Tropical de São Paulo, 1984
Amostras de soros humanos coletadas nas cidades de Pelotas, Santiago e Uruguaiana, no Estado do Rio Grande do Sul, foram testadas para anticorpos inibidores da hemaglutinação contra reovírus.
Ivo Gomes de Mattos, Inguelore S. de Souza, Telmo Vidor   +2 more
doaj   +1 more source

Novel Duck Orthoreovirus Induces Ferroptosis in HD11 Cells by Hijacking Cellular Iron Metabolism and Promoting Iron Accumulation

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Novel duck orthoreovirus (NDRV) infection induces severe splenic necrosis in ducks, resulting in a cascade of detrimental consequences, including immunosuppression, secondary infections, and diminished vaccine efficacy. Avian orthoreovirus (ARV) exhibits high tropism for macrophages, with splenic macrophages being identified as the primary target cells
Hongzhi Wang, Di Lei, Chenchen Jiang, Boyi Xu, Yi Tang, Rendong Fang, Zongfu Wu   +6 more
wiley   +1 more source

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg   +3 more
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