Results 31 to 40 of about 2,272,622 (291)

Role of autophagy in hypoxia-reoxygenation-induced injury of rat alveolar epithelial cell type Ⅱ [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the role of autophagy in the hypoxia-reoxygenation (H/R) model of rat alveolar epithelial cell type Ⅱ (AEC Ⅱ). Methods Cells were randomly divided into control group (C),hypoxia-reoxygenation group (H/R),solvent group
LIU Xiu-jie, WANG Xin-yun, SONG Zheng-yang, LOU Guo-qiang, HAO Mao-lin, QIAN Wei, WANG Wan-tie
doaj  

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Nature, 2014
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and stroke.
Edward T. Chouchani, V. Pell, E. Gaude, D. Aksentijević, Stephanie Y. Sundier, Ellen L. Robb, A. Logan, S. Nadtochiy, E. N. Ord, Anthony C. Smith, Filmon Eyassu, R. Shirley, Chou-Hui Hu, A. Dare, A. James, Sebastian Rogatti, R. Hartley, S. Eaton, Ana S. H. Costa, P. Brookes, S. Davidson, M. Duchen, K. Saeb‐Parsy, M. Shattock, A. Robinson, L. Work, C. Frezza, T. Krieg, M. Murphy   +28 more
semanticscholar   +1 more source

Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction.

Kidney International, 2021
Kidney tubular epithelial cells are high energy-consuming epithelial cells that depend mainly on fatty acid oxidation for an energy supply. AMP-activated protein kinase (AMPK) is a key regulator of energy production in most cells, but the function of ...
Haijian Ma, Xiaozhen Guo, Shichao Cui, Yongmei Wu, Yangming Zhang, Xiaoyan Shen, Cen Xie, Jing-Ya Li   +7 more
semanticscholar   +1 more source

Epithelial Cell-Neutrophil Interactions in the Alimentary Tract: A Complex Dialog in Mucosal Surveillance and Inflammation

The Scientific World Journal, 2002
Inflammatory diseases of mucosal organs as diverse as the lung, kidney, and intestine, inevitably require the intimate interactions of neutrophils with columnar epithelia.
Sean P. Colgan, Katrina M. Comerford, Donald W. Lawrence   +2 more
doaj   +1 more source

Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators

Journal of Lipid Research, 2005
Lipid mediators (LMs) derived from PUFAs play important roles in health and disease. Databases and search algorithms are crucial, but currently unavailable, for accurate and prompt analysis of LMs via liquid chromatography-ultraviolet-tandem mass ...
Yan Lu, Song Hong, Eric Tjonahen, Charles N. Serhan   +3 more
doaj   +1 more source

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Journal of Clinical Medicine, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Gertrude J. Nieuwenhuijs-Moeke, S. Pischke, S. Berger, J. Sanders, R. Pol, M. Struys, R. Ploeg, H. Leuvenink   +7 more
semanticscholar   +1 more source

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2018
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections.
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats. [PDF]

PLoS ONE, 2018
BACKGROUND:Diabetic patients are susceptible to renal ischemia-reperfusion injury, which leads to perioperative complications. Activation of NOD-like receptor protein 3 (NLRP3) inflammasome participates in the development of diabetes, and contributes to ...
Seung Hyun Kim, Ji Hae Jun, Ju Eun Oh, Eun-Jung Shin, Young Jun Oh, Yong Seon Choi   +5 more
doaj   +1 more source

Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway

Frontiers in Cardiovascular Medicine, 2021
Myocardial ischemia/reperfusion injury is a common clinical problem and can result in severe cardiac dysfunction. Previous studies have demonstrated the protection of electroacupuncture against myocardial ischemia/reperfusion injury. However, the role of
Nisha Wang, Jipeng Ma, Yan Ma, Linhe Lu, Chao Ma, Pei Qin, Erhe Gao, Mingzhang Zuo, Jian Yang, Lifang Yang   +9 more
doaj   +1 more source

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury

Acta Pharmaceutica Sinica B, 2020
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury. Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that preserve mitochondrial structure and function, ensure cardiomyocyte survival ...
Jin Wang, Hao Zhou
semanticscholar   +1 more source