Results 51 to 60 of about 199,098 (313)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

eLife
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory.
Fangyan Wang, Xiujie Liu, Furong Huang, Yan Zhou, Xinyu Wang, Zhengyang Song, Sisi Wang, Xiaoting Wang, Dibang Shi, Gaoyi Ruan, Xiawei Ji, Eryao Zhang, Zenglin Tan, Yuqing Ye, Chuang Wang, Jesse Zhu, Wantie Wang   +16 more
doaj   +1 more source

Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats

Journal of Pharmacological Sciences, 2019
Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously revealed that pre-treatment with yohimbine or JP-1302 attenuated renal ischemia/reperfusion injury by inhibition of α2C-adrenoceptor antagonist.
Takaomi Shimokawa, Hidenobu Tsutsui, Takeshi Miura, Masashi Takama, Kohei Hayashi, Toru Nishinaka, Tomoyuki Terada, Kozo Yoneda, Masayo Yamagata, Tokihito Yukimura   +9 more
doaj   +1 more source

AG490 protects cerebral ischemia/reperfusion injury via inhibiting the JAK2/3 signaling pathway

Brain and Behavior, 2021
Background Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia. Brain injury caused by the immune response is important in the pathogenesis of cerebral ischemia/reperfusion injury and immune pathways.
Lichao Fan, Lichun Zhou
doaj   +1 more source

The roles of microRNAs in spinal cord ischemia-reperfusion injury

Neural Regeneration Research, 2022
Spinal cord ischemia/reperfusion injury is a devastating medical disorder with poor prognosis that is associated with several pathophysiological conditions. However, multiple stimuli can trigger SCII, so the underlying mechanism of this pathology has not
Feng-Shou Chen, Xiang-Yi Tong, Bo Fang, Dan Wang, Xiao-Qian Li, Zai-Li Zhang   +5 more
doaj   +1 more source

A novel laser-doppler flowmetry assisted murine model of acute hindlimb ischemia-reperfusion for free flap research

, 2013
Suitable and reproducible experimental models of translational research in reconstructive surgery that allow in-vivo investigation of diverse molecular and cellular mechanisms are still limited.
Isabella Kanzler, Matthias Knobe, Christoph Jan Wruck, Frank Hölzle, Brandacher, Gerald, Nancy Tuchscheerer, David Mitchell, Athanassios Fragoulis, Hölzle, Frank, Kanatas, Anastasios, Mitchell, David, Wruck, Christoph Jan, Othman Al-Sawaf, René Tolba, Knobe, Matthias, Tohidnezhad, Mersedeh, Elisa Anamaria Liehn, Liehn, Elisa Anamaria, Sönmez, Tolga Taha, Anastasios Kanatas, Thomas Pufe, Pufe, Thomas, Al-Sawaf, Othman, Kanzler, Isabella, Tolga Taha Sönmez, Tolba, René H., Fragoulis, Athanassios, Mitchell, David A., Tuchscheerer, Nancy, Gerald Brandacher, Mersedeh Tohidnezhad   +30 more
core   +1 more source

Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts [PDF]

, 2010
Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors.
Winter, H., Waldner, H., Löhe, F., Eichhorn, M. E., Massberg, S., Preissler, G., Messmer, K.   +6 more
core   +1 more source

Ischemia-Reperfusion Injury and Anesthesia [PDF]

BioMed Research International, 2014
Ischemia-reperfusion injury represents a pathological condition characterized by an initial undersupply of blood to an area or organ followed by a restoration of perfusion and concomitant reoxygenation (= reperfusion). Ischemia typically occurs in the presence of embolism or thrombosis but can also be triggered by surgery and transplantation.
Zarbock, Alexander, Eroglu, Ahmet, Erturk, Engin, Ince, Can, Westphal, Martin   +4 more
openaire   +3 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Toll‐like receptor 7 stimulates production of specialized pro‐resolving lipid mediators and promotes resolution of airway inflammation

EMBO Molecular Medicine, 2013
Although specialized pro‐resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive.
Ourania Koltsida, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini‐Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N. Serhan, Evangelos Andreakos   +8 more
doaj   +1 more source