Results 1 to 10 of about 705,796 (337)

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2023
Background High-risk human papillomavirus (HPV) is a primary cause of an increasing number of oropharyngeal squamous cell carcinomas (OPSCCs). The viral etiology of these cancers provides the opportunity for antigen-directed therapies that are restricted
Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon   +12 more
doaj   +1 more source

Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases

Viruses, 2023
T-cell recognition of antigen epitopes is a crucial step for the induction of adaptive immune responses, and the identification of such T-cell epitopes is, therefore, important for understanding diverse immune responses and controlling T-cell immunity. A
Yukio Nakamura, Meng Ling Moi, Takashi Shiina, Tadasu Shin-I, Ryuji Suzuki   +4 more
doaj   +1 more source

Bosnian Drama and Theater: Some Literary and Theatrical Aspects

Društvene i Humanističke Studije, 2021
This text is an introduction to the thematic block of the journal Social Sciences and Humanities Studies on the literary and theatrical aspects of Bosnian drama and theater.
Almir Bašović
doaj   +1 more source

Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires

Frontiers in Immunology, 2023
The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive immune responses, activated B cells duplicate and undergo somatic hypermutation in their B-cell
Aurelien Pelissier, Aurelien Pelissier, Siyuan Luo, Siyuan Luo, Maria Stratigopoulou, Jeroen E. J. Guikema, María Rodríguez Martínez   +6 more
doaj   +1 more source

Ligao City’s Folklore: A Repertoire of Culture and Tradition, An Anthology of Indigenous Healing

Journal of Education, Management and Development Studies, 2022
The study is centered on the narratives on indigenous healing practices of Ligao City, Albay province, Philippines. It gathered genres, documented repertoire, validated text authenticity, translated texts into vernacular, and classified the typology of ...
Anacito Dematera
doaj   +1 more source

Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis

Frontiers in Immunology, 2017
A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties ...
Kazutaka Kitaura, Hiroshi Yamashita, Hitomi Ayabe, Tadasu Shini, Tadasu Shini, Takaji Matsutani, Ryuji Suzuki, Ryuji Suzuki   +7 more
doaj   +1 more source

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

eLife, 2021
Several human B cell subpopulations are recognised in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and class ...
Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Charlotte M Deane, Johannes Trück   +5 more
doaj   +1 more source

Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study

Frontiers in Immunology, 2022
The changes occurring in the T cell repertoire during clinical malaria infection in children remain unknown. In this study, we undertook the first detailed comparative study of the T cell repertoire in African children with and without clinical malaria ...
Augustina Frimpong, Augustina Frimpong, Augustina Frimpong, Michael Fokuo Ofori, Michael Fokuo Ofori, Abdoelnaser M. Degoot, Kwadwo Asamoah Kusi, Kwadwo Asamoah Kusi, Buri Gershom, Jacob Quartey, Eric Kyei-Baafour, Nhi Nguyen, Wilfred Ndifon, Wilfred Ndifon   +13 more
doaj   +1 more source

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

Frontiers in Immunology, 2022
Immunoglobulin gene heterogeneity reflects the diversity and focus of the humoral immune response towards different infections, enabling inference of B cell development processes.
Alexander Stewart, Emma Sinclair, Joseph Chi-Fung Ng, Joselli Silva O’Hare, Joselli Silva O’Hare, Audrey Page, Ilaria Serangeli, Christian Margreitter, Federica Orsenigo, Federica Orsenigo, Katherine Longman, Cecile Frampas, Catia Costa, Holly-May Lewis, Nora Kasar, Bryan Wu, David Kipling, Peter JM Openshaw, Christopher Chiu, J Kenneth Baillie, Janet T. Scott, Malcolm G. Semple, Melanie J. Bailey, Franca Fraternali, Deborah K. Dunn-Walters   +24 more
doaj   +1 more source

Evolutionary ecology of opsin gene sequence, expression and repertoire. [PDF]

, 2017
Linking molecular evolution to biological function is a long-standing challenge in evolutionary biology. Some of the best examples of this involve opsins, the genes that encode the molecular basis of light reception.
Owens, Gregory L, Rennison, Diana J
core   +1 more source