Results 21 to 30 of about 169,378 (259)

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Nature Communications, 2020
Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC.
Alexandre Reuben, Jiexin Zhang, S. Chiou, R. Gittelman, Jun Li, Won-Chul Lee, J. Fujimoto, C. Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, F. Kheradmand, Runzhe Chen, C. Chow, Heather Y Lin, C. Bernatchez, Ali Jalali, Xinchun Hu, Chang-Jiun Wu, A. K. Eterovic, E. Parra, E. Yusko, R. Emerson, S. Benzeno, M. Vignali, Xifeng Wu, Y. Ye, L. Little, C. Gumbs, X. Mao, Xingzhi Song, S. Tippen, Rebecca L. Thornton, T. Cascone, A. Snyder, J. Wargo, R. Herbst, S. Swisher, H. Kadara, C. Moran, N. Kalhor, Jianhua Zhang, P. Scheet, A. Vaporciyan, B. Sepesi, D. Gibbons, H. Robins, P. Hwu, J. Heymach, Padmanee Sharma, James P. Allison, Veerabahdran Baladandayuthapani, Jack J Lee, M. Davis, I. Wistuba, P. A. Futreal, Jianjun Zhang   +57 more
semanticscholar   +1 more source

Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia

OncoImmunology, 2018
Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed ...
Takero Shindo, Kazutaka Kitaura, Hiroshi Ureshino, Kazuharu Kamachi, Masaharu Miyahara, Kazuko Doi, Tatsuro Watanabe, Eisaburo Sueoka, Tadasu Shin-I, Ryuji Suzuki, Shinya Kimura   +10 more
doaj   +1 more source

Identifying specificity groups in the T cell receptor repertoire

Nature, 2017
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual. Here we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using a panel of
J. Glanville, Huang Huang, Allison N. Nau, O. Hatton, Lisa E. Wagar, F. Rubelt, X. Ji, A. Han, S. Krams, Christina Pettus, Nikhil Haas, C. L. Arlehamn, A. Sette, S. Boyd, T. Scriba, O. Martinez, Mark M. Davis   +16 more
semanticscholar   +1 more source

T-cell repertoire analysis and metrics of diversity and clonality.

Current Opinion in Biotechnology, 2020
The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics.
Johanna Chiffelle, R. Genolet, Marta A. S. Perez, G. Coukos, V. Zoete, A. Harari   +5 more
semanticscholar   +1 more source

T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications

Cancer Communications, 2020
T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li, Jiani Yuan, Wenjia Tian, Lin Meng, Yongyu Liu   +4 more
doaj   +1 more source

Next-Generation Immune Repertoire Sequencing as a Clue to Elucidate the Landscape of Immune Modulation by Host–Gut Microbiome Interactions

Frontiers in Immunology, 2018
The human immune system is a fine network consisted of the innumerable numbers of functional cells that balance the immunity and tolerance against various endogenous and environmental challenges.
Tatsuo Ichinohe, Takahiko Miyama, Takakazu Kawase, Yasuko Honjo, Kazutaka Kitaura, Hiroyuki Sato, Tadasu Shin-I, Ryuji Suzuki, Ryuji Suzuki   +8 more
doaj   +1 more source

The substrate repertoire of γ-secretase/presenilin.

Seminars in Cell and Developmental Biology, 2020
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with presenilin as the catalytic subunit and cleaves its membrane protein substrates within their single transmembrane domains.
Gökhan Güner, S. Lichtenthaler
semanticscholar   +1 more source

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Frontiers in Immunology, 2019
Next generation sequencing (NGS) of immunoglobulin (Ig) repertoires (Rep-seq) enables examination of the adaptive immune system at an unprecedented level. Applications include studies of expressed repertoires, gene usage, somatic hypermutation levels, Ig
Néstor Vázquez Bernat, Martin Corcoran, Uta Hardt, Uta Hardt, Mateusz Kaduk, Ganesh E. Phad, Marcel Martin, Gunilla B. Karlsson Hedestam   +7 more
doaj   +1 more source

Quality assessment of gene repertoire annotations with OMArk

Nature Biotechnology
In the era of biodiversity genomics, it is crucial to ensure that annotations of protein-coding gene repertoires are accurate. State-of-the-art tools to assess genome annotations measure the completeness of a gene repertoire but are blind to other errors,
Yannis Nevers, Alex Warwick Vesztrocy, Victor Rossier, Clément-Marie Train, A. Altenhoff, Christophe Dessimoz, Natasha M. Glover   +6 more
semanticscholar   +1 more source

Positive and negative selection of the T cell repertoire: what thymocytes see and don't see

Nature reviews. Immunology, 2014
The fate of developing T cells is specified by the interaction of their antigen receptors with self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs).
L. Klein, B. Kyewski, P. Allen, K. Hogquist   +3 more
semanticscholar   +1 more source