Results 31 to 40 of about 360,824 (309)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis
Scientific ReportsWhile cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli +6 more
doaj +1 more source
Repertoire Class: September 17, 1964 [PDF]
, 1964 This is the program for the Repertoire Class recital, held on September 17, 1964.
Division of Music, Repertoire Class
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
SYMPHONY NO. 3 FOR BAND ORCHESTRA BY VICTOR SIMONOV: STRUCTURAL AND INTERPRETATIVE PARTICULARS [PDF]
Studiul Artelor şi Culturologie: Istorie, Teorie, PracticăThe brass band occupies an important place in the social and cultural life of the Republic of Moldova. The repertoire dedicated to the brass band, in terms of musical genre, is diverse: from marches, academic creations, to folk, entertainment, pop-rock ...
BADRAJAN, SVETLANA, CAZACU, OLEG
doaj +1 more source
Repertoire Class: January 17, 1974 [PDF]
, 1974 This is the program for the Repertoire Class recital, held January 17, 1974.
Division of Music, Repertoire Class
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Repertoire Class: September 28, 1961 [PDF]
, 1961 This is the program for the Repertoire Class recital, held on September 28, 1961. Pianist Sara St.
Division of Music, Repertoire Class
core
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Innate immunity and training to subvert original antigenic sin by the humoral immune response
eLifeOriginally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Faez Amokrane Nait Mohamed +1 more
doaj +1 more source