Results 11 to 20 of about 205,704 (259)
Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
eLife, 2021 Several human B cell subpopulations are recognised in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and class ...
Marie Ghraichy +5 more
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OncoImmunology, 2018 Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed ...
Takero Shindo +10 more
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Frontiers in Immunology, 2018 The human immune system is a fine network consisted of the innumerable numbers of functional cells that balance the immunity and tolerance against various endogenous and environmental challenges.
Tatsuo Ichinohe +8 more
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Norwegian Military Music and Edvard Grieg – an approach
Studia Musicologica Norvegica, 2018 Since both Edvard Grieg’s 175th birthday and Norwegian military music’s 200th anniversary are celebrated in 2018, a first look at compositions by Grieg for military music was in order. As one of Norway’s most popular and beloved composers, his works made
Ina Rupprecht
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Frontiers in Immunology, 2023 The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive immune responses, activated B cells duplicate and undergo somatic hypermutation in their B-cell
Aurelien Pelissier +6 more
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Repertoire-dependent immunopathology [PDF]
Journal of Autoimmunity, 2007 In humans, limited T-cell receptor repertoire and lymphopenia are associated with severe eosinophilic inflammatory disease. A model of lymphopenia and reduced T-cell repertoire was created; C57BL/6 Rag2-/- mice received limited (30,000) or large (2 million) numbers of CD4 T-cells.
Joshua, Milner +4 more
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Frontiers in ImmunologyIntroductionHuman peripheral blood mononuclear cells (hPBMCs) are widely used in fundamental research and clinical applications as studying their responses to in vitro activation is an effective way to uncover functional alterations and disease ...
Aline Linder +3 more
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Human Vaccines & Immunotherapeutics, 2021 The Hepatitis B (HB) vaccine is efficacious in preventing hepatitis B virus infection. However, the association between antibody response to the HB vaccine and dynamic immune repertoire changes in different cell subsets remains unclear.
Miaoxian Zhao +8 more
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Evolution of T cell receptor beta loci in salmonids
Frontiers in Immunology, 2023 T-cell mediated immunity relies on a vast array of antigen specific T cell receptors (TR). Characterizing the structure of TR loci is essential to study the diversity and composition of T cell responses in vertebrate species.
Pierre Boudinot +6 more
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Analyzing Immunoglobulin Repertoires [PDF]
Frontiers in Immunology, 2018 Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput sequencing of lymphocyte antigen receptor genes has recently generated unprecedented opportunities for exploration of adaptive immune responses.
Chaudhary, Neha, Wesemann, Duane
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