Results 61 to 70 of about 169,378 (259)

Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire

Frontiers in Immunology, 2013
In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible
Veronika eZarnitsyna, Brian eEvavold, Louie eSchoettle, Joseph eBlattman, Rustom eAntia   +4 more
doaj   +1 more source

Ligao City’s Folklore: A Repertoire of Culture and Tradition, An Anthology of Indigenous Healing

Journal of Education, Management and Development Studies, 2022
The study is centered on the narratives on indigenous healing practices of Ligao City, Albay province, Philippines. It gathered genres, documented repertoire, validated text authenticity, translated texts into vernacular, and classified the typology of ...
Anacito Dematera
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Clinical Features and T‐Cell Repertoire of Chronic Myeloid Leukemia Patients Who Attempt Discontinuation of Tyrosine Kinase Inhibitors: The ISAC‐TFR Study

Cancer Medicine
Background While tyrosine kinase inhibitor (TKI) discontinuation is an established therapeutic goal, up to 60% of patients relapse after the first attempt. The feasibility of a second or third attempt at TKI discontinuation remains uncertain.
Hiroshi Ureshino, Yukio Nakamura, Yemima Budirahardja, Iwao Nozawa, Keisuke Kidoguchi, Kazuharu Kamachi, Shinya Kimura   +6 more
doaj   +1 more source

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

Frontiers in Immunology, 2022
Immunoglobulin gene heterogeneity reflects the diversity and focus of the humoral immune response towards different infections, enabling inference of B cell development processes.
Alexander Stewart, Emma Sinclair, Joseph Chi-Fung Ng, Joselli Silva O’Hare, Joselli Silva O’Hare, Audrey Page, Ilaria Serangeli, Christian Margreitter, Federica Orsenigo, Federica Orsenigo, Katherine Longman, Cecile Frampas, Catia Costa, Holly-May Lewis, Nora Kasar, Bryan Wu, David Kipling, Peter JM Openshaw, Christopher Chiu, J Kenneth Baillie, Janet T. Scott, Malcolm G. Semple, Melanie J. Bailey, Franca Fraternali, Deborah K. Dunn-Walters   +24 more
doaj   +1 more source

Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients

Frontiers in Immunology, 2020
Severe COVID-19 is associated with profound lymphopenia and an elevated neutrophil to lymphocyte ratio. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR)
Xuefeng Niu, Song Li, Pingchao Li, Wenjing Pan, Qian Wang, Ying Feng, Xiao-Neng Mo, Q. Yan, Xianmiao Ye, Jia Luo, Linbing Qu, Daniel Weber, M. Byrne-Steele, Zhe Wang, Fengjia Yu, Fang Li, R. Myers, M. Lotze, N. Zhong, Jian Han, Ling Chen   +20 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Repertoire-dependent immunopathology [PDF]

Journal of Autoimmunity, 2007
In humans, limited T-cell receptor repertoire and lymphopenia are associated with severe eosinophilic inflammatory disease. A model of lymphopenia and reduced T-cell repertoire was created; C57BL/6 Rag2-/- mice received limited (30,000) or large (2 million) numbers of CD4 T-cells.
Joshua, Milner, Jerrold, Ward, Andrea, Keane-Myers, Booki, Min, William E, Paul   +4 more
openaire   +2 more sources

WORKING WITH JAZZ PERCUSSIONISTS IN THE VIBRAPHONE CLASS [PDF]

Studiul Artelor şi Culturologie: Istorie, Teorie, Practică, 2015
The present article approaches some aspects of teaching students whose major is light music and jazz instruments (percus­sion instruments) in the vibraphone class.
BEREZOVICOVA TATIANA, MIHAILOVA ZOIA
doaj  

Natural Killer Cell Diversity in Viral Infection: Why and How Much?

Pathogens and Immunity, 2016
Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly respond to cancerous or virus-infected cells. NK cell function is controlled by the integration of signals from activating and inhibitory receptors expressed ...
Catherine A. Blish
doaj   +1 more source