Results 71 to 80 of about 889,250 (400)

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

Scientific Reports
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli, Daniela Rodrigues, Kevin Portmann, Aline Linder, Marina Thoma, Cornelia Halin, Klaus Eyer   +6 more
doaj   +1 more source

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

eLife, 2015
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity.
Neha R Deshpande, Heather L Parrish, Michael S Kuhns   +2 more
doaj   +1 more source

Three phases in the evolution of the standard genetic code: how translation could get started [PDF]

, 2007
A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like.
van der Gulik, Peter
core   +1 more source

A comparison of facial expression properties in five hylobatid species [PDF]

, 2014
Little is known about facial communication of lesser apes (family Hylobatidae) and how their facial expressions (and use of) relate to social organization.
Altmann, Berkson, Bewick, Black, Blomberg, Brockelmann, Burrows, Burrows, Caeiro, Chan, Chivers, Chivers, Chivers, Chivers, Cohen, Conover, de Waal, Diogo, Dobson, Dunbar, Dunbar, Dunbar, Ekman, Ekman, Fischer, Flack, Fox, Freeberg, Fuentes, Geissmann, Geissmann, Gittins, Gowaty, Haimhoff, Hill, Kenyon, Kroodsma, Lappan, Liebal, Maestripieri, Mootnick, Mootnick, Orgeldinger, Palombit, Parr, Parr, Preuschoft, Preuschoft, Raemaekers, Reichard, Reichard, Reichard, Reichard, Rowe, Shannon, Shultz, Shultz, Sprent, Thierry, Thierry, Thin, van Hooff, Vick, Waller, Waller, Waller, Waller, Westneat, Zhou   +68 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The influences of microbial colonisation and germ-free status on the chicken TCRβ repertoire

Frontiers in Immunology, 2023
Microbial colonisation is paramount to the normal development of the immune system, particularly at mucosal sites. However, the relationships between the microbiome and the adaptive immune repertoire have mostly been explored in rodents and humans. Here,
Stefan Dascalu, Stefan Dascalu, Stephen G. Preston, Stephen G. Preston, Robert J. Dixon, Patrik G. Flammer, Steven Fiddaman, Amy Boyd, Joshua E. Sealy, Jean-Remy Sadeyen, Bernd Kaspers, Philippe Velge, Munir Iqbal, Michael B. Bonsall, Adrian L. Smith   +14 more
doaj   +1 more source

The size of the immune repertoire of bacteria

, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay, Bradde, Serena, Goyal, Sidhartha, Nourmohammad, Armita   +3 more
core   +1 more source

Personal style and epistemic stance in classroom discussion [PDF]

, 2011
This article reports on an analysis of stance-taking in the university classroom, examining how students position themselves in relation to academic knowledge through the epistemic phrases I don’t know and I think.
Kirkham, Sam
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies

Frontiers in Immunology, 2018
Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat human disease. Increasingly, therapeutic antibodies are discovered using transgenic animal systems that have been engineered to express human antibodies ...
Weihsu C. Chen, Christopher M. Murawsky
doaj   +1 more source