Results 31 to 40 of about 1,185,258 (299)

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Nature Communications
The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck   +11 more
doaj   +1 more source

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal

Viruses
During HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag–Psi interactions, there is almost no information on
Constance Rink, Tomas Kroupa, Siddhartha A. K. Datta, Alan Rein   +3 more
doaj   +1 more source

Cdt1 stabilizes an open MCM ring for helicase loading

Nature Communications, 2017
The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading ...
Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley   +9 more
doaj   +1 more source

Replication in Economics [PDF]

SSRN Electronic Journal, 2007
This examination of the role and potential for replication in economics points out the paucity of both pure replication - checking on others' published papers using their data - and scientific replication - using data representing different populations in one's own work or in a Comment.
Daniel S. Hamermesh, Daniel S. Hamermesh, Daniel S. Hamermesh   +2 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Nature Communications
Human DNA licensing initiates replication fork assembly and DNA replication. This reaction promotes the loading of the hMCM2-7 complex on DNA, which represents the core of the replicative helicase that unwinds DNA during S-phase.
Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala-Stavridi, Sarah V. Faull, Ricardo Aramayo, Carolina M. Pestana, Lepakshi Ranjha, Christian Speck   +11 more
doaj   +1 more source

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Viruses
During retrovirus assembly, Gag packages unspliced viral RNA as the virion genome. Genome packaging is usually specific with occasional exceptions of cross-packaging RNA from distantly related retroviruses.
Zetao Cheng, Olga A. Nikolaitchik, Alice Duchon, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Replication, Replication [PDF]

PS: Political Science & Politics, 1995
Political science is a community enterprise; the community of empirical political scientists needs access to the body of data necessary to replicate existing studies to understand, evaluate, and especially build on this work. Unfortunately, the norms we have in place now do not encourage, or in some cases even permit, this aim.
openaire   +2 more sources