Results 31 to 40 of about 3,159,718 (373)
The role of integration and clonal expansion in HIV infection: live long and prosper
Retrovirology, 2018 Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
doaj +1 more source
IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag
mBio, 2020 Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses.
Yadvinder S. Ahi +6 more
doaj +1 more source
Journal of the American Medical Association (JAMA), 2003 CONTEXT Uncertainties exist about prevalence and correlates of major depressive disorder (MDD). OBJECTIVE To present nationally representative data on prevalence and correlates of MDD by Diagnostic and Statistical Manual of Mental Disorders, Fourth ...
R. Kessler +8 more
semanticscholar +1 more source
Efficient support of virus-like particle assembly by the HIV-1 packaging signal
eLife, 2018 The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia +5 more
doaj +1 more source
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
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Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
core +2 more sources
Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
doaj +1 more source
Coronaviruses: An Overview of Their Replication and Pathogenesis
Methods in molecular biology, 2015 Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy.
Anthony R. Fehr, S. Perlman
semanticscholar +1 more source
Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication [PDF]
, 2010 Background Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the
Castorena, Kathryn M +2 more
core +4 more sources
Microbiology Spectrum, 2022 HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson +5 more
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