Results 41 to 50 of about 1,185,258 (299)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA

Viruses, 2020
Viral genomic RNA is packaged into virions with high specificity and selectivity. However, in vitro the Gag specificity towards viral RNA is obscured when measured in buffers containing physiological salt. Interestingly, when the binding is challenged by
Tomas Kroupa, Siddhartha A. K. Datta, Alan Rein   +2 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Structural Insights into APOBEC3-Mediated Lentiviral Restriction

Viruses, 2020
Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of ...
Krista A. Delviks-Frankenberry, Belete A. Desimmie, Vinay K. Pathak   +2 more
doaj   +1 more source

The Replication Database: Documenting the Replicability of Psychological Science [PDF]

Journal of Open Psychology Data
In psychological science, replicability—repeating a study with a new sampleachieving consistent results (Parsons et al., 2022)—is critical for affirming the validity of scientific findings. Despite its importance, replication efforts are few and far between in psychological science with many attempts failing to corroborate past findings. This scarcity,
Lukas Röseler, Leonard Kaiser, Christopher Doetsch, Noah Klett, Christian Seida, Astrid Schütz, Balazs Aczel, Nadia Adelina, Valeria Agostini, Samuel Alarie, Nihan Albayrak-Aydemir, Alaa Aldoh, Ali H. Al-Hoorie, Flavio Azevedo, Bradley J. Baker, Charlotte Lilian Barth, Julia Beitner, Cameron Brick, Hilmar Brohmer, Subramanya Prasad Chandrashekar, Kai Li Chung, Jamie P. Cockcroft, Jamie Cummins, Veronica Diveica, Tsvetomira Dumbalska, Emir Efendic, Mahmoud Elsherif, Thomas Evans, Gilad Feldman, Adrien Fillon, Nico Förster, Joris Frese, Oliver Genschow, Vaitsa Giannouli, Biljana Gjoneska, Timo Gnambs, Amélie Gourdon-Kanhukamwe, Christopher J. Graham, Helena Hartmann, Clove Haviva, Alina Herderich, Leon P. Hilbert, Darías Holgado, Ian Hussey, Zlatomira G. Ilchovska, Tamara Kalandadze, Veli-Matti Karhulahti, Leon Kasseckert, Maren Klingelhöfer-Jens, Alina Koppold, Max Korbmacher, Louisa Kulke, Niclas Kuper, Annalise LaPlume, Gavin Leech, Feline Lohkamp, Nigel Mantou Lou, Dermot Lynott, Maximilian Maier, Maria Meier, Maria Montefinese, David Moreau, Kellen Mrkva, Monika Nemcova, Danna Oomen, Julian Packheiser, Shubham Pandey, Frank Papenmeier, Mariola Paruzel-Czachura, Yuri G. Pavlov, Zoran Pavlović, Charlotte R. Pennington, Merle-Marie Pittelkow, Willemijn Plomp, Paul E. Plonski, Ekaterina Pronizius, Andrew Adrian Pua, Katarzyna Pypno-Blajda, Manuel Rausch, Tobias R. Rebholz, Elena Richert, Jan Philipp Röer, Robert Ross, Kathleen Schmidt, Aleksandrina Skvortsova, Matthias F. J. Sperl, Alvin W. M. Tan, J. Lukas Thürmer, Aleksandra Tołopiło, Wolf Vanpaemel, Leigh Ann Vaughn, Steven Verheyen, Lukas Wallrich, Lucia Weber, Julia K. Wolska, Mirela Zaneva, Yikang Zhang   +96 more
openaire   +13 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

The Contribution of Lysosomes to DNA Replication

Cells, 2021
Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for
Joanna Maria Merchut-Maya, Apolinar Maya-Mendoza   +1 more
doaj   +1 more source

Peer Replication

, 2023
To help end the replication crisis and instill confidence in our scientific literature, we introduce a new process for evaluating scientific manuscripts, termed “peer replication,” in which referees independently reproduce key experiments of a manuscript.
Lord, Samuel J., Charles-Orszag, Arthur, Skruber, Kristen, Mullins, R. Dyche, Rehfeld, Anders   +4 more
openaire   +2 more sources