Results 241 to 250 of about 1,088,807 (293)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Genome-wide mapping of RPA1 and RAD9 reveals the management of polycistronic transcription, replication initiation, and responses to replication stress in Leishmania

Black J, Virgilio S, Bastos M, Silva G, Damasceno J, Lapsley C, McCulloch R, Tosi L.   +7 more
europepmc   +1 more source

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The Initiation of Eukaryotic DNA Replication

Annual Review of Biochemistry, 2022
DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle. This is accomplished through the regulation of the first two steps in replication: loading and activation ...
Alessandro, Costa, John F X, Diffley
openaire   +2 more sources

Initiation of archaeal DNA replication

Biochemical Society Transactions, 2003
The identification of DNA as the genetic material and the elucidation of its structure by Watson and Crick [Watson and Crick, (1953) Nature (London) 171, 737–738], which has its 50th anniversary this year, first suggested the simple elegance with which the problem of passing on precise genetic information from one generation to the next could be solved.
E R, Jenkinson, J P J, Chong
openaire   +2 more sources

REGULATION OF INITIATION OF DNA REPLICATION

Annual Review of Genetics, 1979
INTRODUCTION 355 UNIQUENESS OF THE SITE OF INITIATION OF REPLICATION 357 STRUCTURE OF THE ORIGIN SITE 359 EVENTS AT THE INITIATION SITE . . . . 362 TRANSCRIPTIONAL ACTIVATION 365 DIRECTIONALITY OF REPLICATION 366 HOST FUNCTIONS REQUIRED FOR INITIATION 367 REPLICON-SPECIFIC INITIATION PROTEINS . . . . . . . . . . ...... ....... ....... .
R, Kolter, D R, Helinski
openaire   +2 more sources

Initiation of adenovirus DNA replication

Journal of Virology, 1980
In an attempt to study the mechanism of initiation of adenovirus DNA replication, an assay was developed to investigate the pattern of DNA synthesis in early replicative intermediates of adenovirus DNA. By using wild-type virus-infected cells, it was possible to place the origin of adenovirus type 2 DNA replication within the terminal 350 to 500 base ...
T, Reiter, J, Fütterer, B, Weingärtner, E L, Winnacker   +3 more
openaire   +2 more sources

Replication Initiation Point Mapping

Methods, 1997
Replication in eukaryotes is bidirectional and semi-discontinuous. This asymmetry provides the basis for mapping the origin of bidirectional replication (OBR), which is the transition point from discontinuous to continuous synthesis. The regions of each DNA strand complementary to the leading strand or lagging strand can be measured by the methods of ...
S A, Gerbi, A K, Bielinsky
openaire   +2 more sources

Clamp loaders and replication initiation

Current Opinion in Structural Biology, 2006
Clamp loaders are ATP-driven multiprotein machines that couple ATP hydrolysis to the opening and closing of a circular protein ring around DNA. This ring-shaped clamp slides along DNA, and interacts with numerous proteins involved in DNA replication, DNA repair and cell cycle control.
Mike, O'Donnell, John, Kuriyan
openaire   +2 more sources