Results 261 to 270 of about 1,088,807 (293)

The complex for replication initiation ofEscherichia coli

Chromosoma, 1992
We probed the complex between oriC and DnaA protein using two types of mutants in oriC. Base changes in the DnaA binding sites, DnaA boxes, had little effect on origin function. Mutations which change the distance between DnaA boxes R3 and R4, on the other hand, inactivated oriC unless the mutation deleted or inserted one complete helical turn. Origins
W, Messer, H, Hartmann-Kühlein, U, Langer, E, Mahlow, A, Roth, S, Schaper, B, Urmoneit, B, Woelker   +7 more
openaire   +2 more sources

Epigenetic landscape for initiation of DNA replication

Chromosoma, 2013
The key genetic process of DNA replication is initiated at specific sites referred to as replication origins. In eukaryotes, origins of DNA replication are not specified by a defined nucleotide sequence. Recent studies have shown that the structural context and topology of DNA sequence, chromatin features, and its transcriptional activity play an ...
Vladimir V, Sherstyuk, Alexander I, Shevchenko, Suren M, Zakian   +2 more
openaire   +2 more sources

Initiation of eukaryotic DNA replication in vitro

BioEssays, 1988
AbstractRecent advances in our understanding of the mechanism and regulation of eukaryotic DNA replication have been expedited by the use of cell‐free systems capable of initiation of DNA replication. The system capable of replicating plasmid DNAs containing the SV40 origin of DNA replication in vitro is a paradigm for studies on the replication of ...
openaire   +3 more sources

Cdt1 and Geminin in DNA Replication Initiation

2012
One of the mechanisms controlling the initiation of DNA replication is the dynamic interaction between Cdt1, which promotes assembly of the pre-replication license complex, and Geminin, which inhibits it. Specifically, Cdt1 cooperates with the cell cycle protein Cdc6 to promote loading of the minichromosome maintenance helicases (MCM) onto the ...
Christophe, Caillat, Anastassis, Perrakis   +1 more
openaire   +2 more sources

Initiation of the Streptomyces chromosome replication

Antonie van Leeuwenhoek, 2000
J, Zakrzewska-Czerwińska, D, Jakimowicz, J, Majka, W, Messer, H, Schrempf   +4 more
openaire   +2 more sources

Multiple mechanisms for overcoming lethal over-initiation of DNA replication

Molecular Microbiology, 2022
Janet Smith, Alan D Grossman, Mary E Anderson   +2 more
exaly  

Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

Molecular Cell, 2021
Kuhulika Bhalla, Bruce William Stillman, Manzar Hossain   +2 more
exaly  

Replication Initiation

2020
openaire   +1 more source

Positive and Negative Regulation of DNA Replication Initiation

Trends in Genetics, 2020
Amnon Koren
exaly  

The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation

EMBO Journal, 2002
Iris V. Hood
exaly