Results 201 to 210 of about 1,971,949 (299)

Quantitative Chromatin Protein Dynamics During Replication Origin Firing in Human Cells. [PDF]

Mol Cell Proteomics
Gadi SA, Hendriks IA, Nielsen CF, Popova P, Hickson ID, Nielsen ML, Toledo L.   +6 more
europepmc   +1 more source

Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency. [PDF]

Genome Biol, 2021
Li Y, Xue B, Zhang M, Zhang L, Hou Y, Qin Y, Long H, Su QP, Wang Y, Guan X, Jin Y, Cao Y, Li G, Sun Y.   +13 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

UV induces codirectional replication-transcription conflicts and an alternative DnaA-dependent replication origin in the rnhAB mutants of Escherichiacoli. [PDF]

Nucleic Acids Res
Kouzminova EA, Cronan GE, Kuzminov A.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

G-quadruplex as an essential structural element in cytomegalovirus replication origin. [PDF]

Nat Commun
Park D, Chung WC, Gong S, Ravichandran S, Lee GM, Han M, Kim KK, Ahn JH.   +7 more
europepmc   +1 more source

RIF1 regulates replication origin activity and early replication timing in B cells

, 2023
Malzl D, Peycheva M, Rahjouei A, Gnan S, Klein KN, Nazarova M, Schoeberl UE, Gilbert DM, Buonomo SCB, Virgilio MD, Neumann T, Pavri R.   +11 more
europepmc   +1 more source

The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin. [PDF]

Life (Basel), 2021
Bauwens S, Lototska L, Koundrioukoff S, Debatisse M, Ye J, Gilson E, Mendez-Bermudez A.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

SSB promotes DnaB helicase passage through DnaA complexes at the replication origin oriC for bidirectional replication. [PDF]

J Biochem
Akama Y, Yoshida R, Ozaki S, Kawakami H, Katayama T.   +4 more
europepmc   +1 more source