Results 201 to 210 of about 1,145,720 (307)

Replication Protein A Phosphorylation Facilitates RAD52-Dependent Homologous Recombination in BRCA-Deficient Cells. [PDF]

Mol Cell Biol, 2022
Carley AC, Jalan M, Subramanyam S, Roy R, Borgstahl GEO, Powell SN.   +5 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Structural and functional studies of the main replication protein NS1 of human parvovirus B19. [PDF]

Nucleic Acids Res
Zhang Y, Fan B, Gao Y, Yang J, Zhang W, Su S, Li L, Li H, Luo Z, Tang G, Wang C, Zhang X, Liu H, Gan J.   +13 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Investigation of truncated replication protein mutant of Canine Circovirus: synergistic interaction with Feline Panleukopenia Virus. [PDF]

Front Vet Sci
Li S, Xin J, Peng Y, Liu H, Zhou Z, Zhong Z, Fu H, Yang M, Li W, Wu R, Peng G.   +10 more
europepmc   +1 more source

Hydrogen-deuterium exchange reveals a dynamic DNA-binding map of replication protein A. [PDF]

Nucleic Acids Res, 2021
Ahmad F, Patterson A, Deveryshetty J, Mattice JR, Pokhrel N, Bothner B, Antony E.   +6 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Biochemical impact of p300-mediated acetylation of replication protein A: Implications for DNA metabolic pathway choice. [PDF]

J Biol Chem
Ononye O, Surendran S, Battapadi T, VanderVere-Carozza P, Howald OK, Kantartzis-Petrides A, Jordan MR, Ainembabazi D, Wold MS, Turchi JJ, Balakrishnan L.   +10 more
europepmc   +1 more source

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. [PDF]

Nat Commun, 2021
Wang L, Li J, Zhou H, Zhang W, Gao J, Zheng P.   +5 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source