Results 31 to 40 of about 34,336 (231)
Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
core +1 more source
A conserved mechanism for regulating replisome disassembly in eukaryotes
Nature, 2021 Replisome disassembly is the final step of eukaryotic DNA replication and is triggered by ubiquitylation of the CDC45–MCM–GINS (CMG) replicative helicase1–3.
M. Jenkyn-Bedford +6 more
semanticscholar +1 more source
Current Opinion in Structural Biology, 2018 Bacterial replisomes are dynamic multiprotein DNA replication machines that are inherently difficult for structural studies. However, breakthroughs continue to come. The structures of Escherichia coli DNA polymerase III (core)-clamp-DNA subcomplexes solved by single-particle cryo-electron microscopy in both polymerization and proofreading modes and the
Zhi-Qiang Xu, Nicholas E Dixon
openaire +3 more sources
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
doaj +1 more source
A link between transcription fidelity and pausing in vivo [PDF]
, 2017 Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source
Gamba, Pamela +2 more
core +2 more sources
The Escherichia coli chromosome moves to the replisome
bioRxiv, 2023 The replisome, a large multi-subunit assembly, carries out the process of chromosome replication, connecting the unwrapping of the parental DNA with the creation of new daughter strands.
K. Gras, D. Fange, J. Elf
semanticscholar +1 more source
Replisome Dynamics during Chromosome Duplication [PDF]
EcoSal Plus, 2009 This review describes the components of the Escherichia coli replisome and the dynamic process in which they function and interact under normal conditions. It also briefly describes the behavior of the replisome during situations in which normal replication fork movement is disturbed, such as when the replication ...
Isabel, Kurth, Mike, O'Donnell
openaire +2 more sources
Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability
Cell Reports, 2020 Summary: DNA replication and RNA transcription compete for the same substrate during S phase. Cells have evolved several mechanisms to minimize such conflicts.
Rowin Appanah +4 more
doaj +1 more source
MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity [PDF]
, 2016 Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in bacteria and lead to human disease.
Argaraña, Carlos Enrique +4 more
core +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source