Results 41 to 50 of about 34,336 (231)
Cell, 2010 In all organisms, successful cell division requires accurate copying of chromosomal DNA. To duplicate their genomes, all cells use a multiprotein apparatus known as the replisome (reviewed by Benkovic et al., 2001; McHenry, 2003; Yao and O’Donnell, 2009).
Yao, Nina Y., O'Donnell, Mike
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Roles of the mitochondrial replisome in mitochondrial DNA deletion formation [PDF]
Genetics and Molecular Biology, 2020 Mitochondrial DNA (mtDNA) deletions are a common cause of human mitochondrial diseases. Mutations in the genes encoding components of the mitochondrial replisome, such as DNA polymerase gamma (Pol γ) and the mtDNA helicase Twinkle, have been associated ...
Marcos T. Oliveira +2 more
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Proficient replication of the yeast genome by a viral DNA polymerase [PDF]
, 2016 DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M +2 more
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Replisome loading reduces chromatin motion independent of DNA synthesis
bioRxiv, 2023 Chromatin has been shown to undergo diffusional motion, which is affected during gene transcription by RNA polymerase activity. However, the relationship between chromatin mobility and other genomic processes remains unclear.
M. K. Pabba +12 more
semanticscholar +1 more source
Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors
Chromosoma, 2023 The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for faithful segregation of DNA replication products during cell divisions.
S. Shrestha +5 more
semanticscholar +1 more source
eLife, 2021 Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in catalysis or binding display ...
Subu Subramanian +7 more
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Replisome‐Cohesin Interfacing: A Molecular Perspective [PDF]
BioEssays, 2018 Cohesion is established in S‐phase through the action of key replisome factors as replication forks engage cohesin molecules. By holding sister chromatids together, cohesion critically assists both an equal segregation of the duplicated genetic material and an efficient repair of DNA breaks.
Villa, Sara, Bermejo, Rodrigo
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Transcription leads to pervasive replisome instability in bacteria
eLife, 2017 The canonical model of DNA replication describes a highly-processive and largely continuous process by which the genome is duplicated. This continuous model is based upon in vitro reconstitution and in vivo ensemble experiments. Here, we characterize the
Sarah M Mangiameli +3 more
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The Response of the Replication Apparatus to Leading Template Strand Blocks
Cells, 2023 Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani +4 more
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“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]
, 2014 The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova +110 more
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