Results 71 to 80 of about 34,336 (231)
T7 replisome directly overcomes DNA damage [PDF]
Nature Communications, 2015 AbstractCells and viruses possess several known ‘restart’ pathways to overcome lesions during DNA replication. However, these ‘bypass’ pathways leave a gap in replicated DNA or require recruitment of accessory proteins, resulting in significant delays to fork movement or even cell division arrest.
Sun, Bo +6 more
openaire +2 more sources
The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria. [PDF]
PLoS Genetics, 2017 The positioning of the DNA replication machinery (replisome) has been the subject of several studies. Two conflicting models for replisome localization have been proposed: In the Factory Model, sister replisomes remain spatially co-localized as the ...
Sarah M Mangiameli +3 more
doaj +1 more source
Single-Molecule Insights Into the Dynamics of Replicative Helicases
Frontiers in Molecular Biosciences, 2021 Helicases are molecular motors that translocate along single-stranded DNA and unwind duplex DNA. They rely on the consumption of chemical energy from nucleotide hydrolysis to drive their translocation.
Richard R. Spinks +7 more
doaj +1 more source
Coordinated DNA Replication by the Bacteriophage T4 Replisome
Viruses, 2015 The T4 bacteriophage encodes eight proteins, which are sufficient to carry out coordinated leading and lagging strand DNA synthesis. These purified proteins have been used to reconstitute DNA synthesis in vitro and are a well-characterized model system ...
Erin Noble +2 more
doaj +1 more source
mBio, 2023 Bacterial DNA methyltransferases (MTases) function in restriction modification systems, cell cycle control, and the regulation of gene expression. DnmA is a recently described DNA MTase that forms N6-methyladenosine at nonpalindromic 5′-GACGAG-3′ sites ...
Nicolas L. Fernandez +6 more
doaj +1 more source
Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]
, 2015 Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers +5 more
core +3 more sources
Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
Nature Communications, 2020 The eukaryotic leading strand DNA polymerase (Pol) ε contains 4 subunits, Pol2, Dpb2, Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic and the C-terminal Pol module is non-catalytic.
Zuanning Yuan +4 more
semanticscholar +1 more source
Antibiotics, 2018 DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino ...
Jon M. Kaguni
doaj +1 more source
Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
Journal of Fish Biology, EarlyView.Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne +4 more
wiley +1 more source