Results 11 to 20 of about 7,567,038 (395)
StORF-Reporter: Finding Genes between Genes [PDF]
Nucleic Acids Research, 2022 Abstract Large regions of prokaryotic genomes are currently without any annotation, in part due to well-established limitations of annotation tools. For example, it is routine for genes using alternative start codons to be misreported or completely omitted.
Nicholas J Dimonaco +4 more
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Positron Emission Tomography Reporter Genes and Reporter Probes: Gene and Cell Therapy Applications [PDF]
Theranostics, 2012 Positron emission tomography (PET) imaging reporter genes (IRGs) and PET reporter probes (PRPs) are amongst the most valuable tools for gene and cell therapy.
Shahriar S. Yaghoubi, Dean O. Campbell, Caius G. Radu, Johannes Czernin
doaj +5 more sources
Journal of Nuclear Medicine, 2008 Noninvasive molecular imaging of dynamic processes has benefited tremendously from the use of reporter genes. These genes encode for proteins that emit light, bind radiolabeled probes, or, as covered in this review, modulate MRI contrast. Reporter genes play a pivotal role in monitoring cell trafficking, gene replacement therapy, protein-protein ...
Assaf A. Gilad +5 more
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Genetically Encoded Reporter Genes for MicroRNA Imaging in Living Cells and Animals
Molecular Therapy: Nucleic Acids, 2020 MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by base paring with the complementary sequences of the target mRNAs, and then exert their function through degrading mRNA or inhibiting protein translation.
Yingzhuang Song, Zhijing Xu, Fu Wang
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Environmental Health Perspectives, 2020 Background: High-throughput screening of chemicals with in vitro reporter gene assays in Tox21 has produced a large database on cytotoxicity and specific modes of action. However, the validity of some of the reported activities is questionable due to the
B. Escher +4 more
semanticscholar +1 more source
Biogenic Imaging Contrast Agents
Advanced Science, 2023 Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular ...
Qing Dan +4 more
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CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]
, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
A Diaz +52 more
core +8 more sources
mBio, 2020 Dynamic changes in transcription profiles are key for the success of pathogens in colonizing their hosts. In many pathogens, genes associated with virulence, such as effector genes, are located in regions of the genome that are rich in transposable ...
Lukas Meile +5 more
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Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once. [PDF]
PLoS ONE, 2010 The molecular mechanisms regulating the activity of the TCRα gene are required for the production of the circulating T cell repertoire. Elements of the mouse TCRα locus control region (LCR) play a role in these processes. We previously reported that TCRα
Stefan Knirr +7 more
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