Results 31 to 40 of about 7,873,006 (309)
Effective gene expression prediction from sequence by integrating long-range interactions
Nature Methods, 2021 How noncoding DNA determines gene expression in different cell types is a major unsolved problem, and critical downstream applications in human genetics depend on improved solutions.
Žiga Avsec +9 more
semanticscholar +1 more source
mCherry contains a fluorescent protein isoform that interferes with its reporter function
Frontiers in Bioengineering and Biotechnology, 2022 Fluorescent proteins are essential reporters in cell and molecular biology. Here, we found that red-fluorescent proteins possess an alternative translation initiation site that produces a short functional protein isoform in both prokaryotes and ...
Maxime Fages-Lartaud +5 more
doaj +1 more source
Positron emission tomography reporter gene strategy for use in the central nervous system
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance With any new treatment it is imperative the medical community has a way to monitor its effectiveness, tracking its location, monitoring its expression, and observing off-target effects. Gene/cell therapy is no exception.
Tom Haywood +6 more
semanticscholar +1 more source
Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration
Frontiers in Neuroscience, 2018 Key scientific discoveries have resulted from genetic studies of Drosophila melanogaster, using a multitude of transgenic fly strains, the majority of which are constructed in a genetic background containing mutations in the white gene.
María José Ferreiro +8 more
doaj +1 more source
Reporter Gene Imaging of Targeted T-Cell Immunotherapy in Recurrent Glioma
Science Translational Medicine, 2017 PET gene reporter imaging can be used to monitor the trafficking of therapeutic cytotoxic T cells in glioma patients. T cells reporting for duty Cytotoxic T cells engineered to kill tumor cells are becoming a mainstay of cancer immunotherapy. However, no
K. V. Keu +16 more
semanticscholar +1 more source
Molecular Imaging, 2005 The human and rodent sodium iodide symporters ( NIS ) have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked human NIS (
Jiantu Che +5 more
doaj +1 more source
CAR Chase: Where Do Engineered Cells Go in Humans?
Frontiers in Oncology, 2020 Chimeric antigen receptor (CAR) – and T-cell receptor (TCR) – modified T-cells are rapidly emerging as a viable treatment option for cancer patients.
Simone Krebs +7 more
doaj +1 more source
Multimodality reporter gene imaging: Construction strategies and application
Theranostics, 2018 Molecular imaging has played an important role in the noninvasive exploration of multiple biological processes. Reporter gene imaging is a key part of molecular imaging.
Mengting Li +3 more
semanticscholar +1 more source
Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter
Microorganisms, 2022 Inteins (intervening proteins) are polypeptides that interrupt the sequence of other proteins and remove themselves through protein splicing. In this intein-catalyzed reaction, the two peptide bonds surrounding the intein are rearranged to release the ...
Baylee Heiden +3 more
doaj +1 more source
The use of the NIS reporter gene for optimizing oncolytic virotherapy
Expert Opinion on Biological Therapy, 2015 Introduction: Oncolytic viruses are experimental cancer therapies being translated to the clinic. They are unique in their ability to amplify within the body, therefore requiring careful monitoring of viral replication and biodistribution.
A. Miller, S. Russell
semanticscholar +1 more source