Results 21 to 30 of about 7,873,006 (309)
Genetically Encoded Reporter Genes for MicroRNA Imaging in Living Cells and Animals
Molecular Therapy: Nucleic Acids, 2020 MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by base paring with the complementary sequences of the target mRNAs, and then exert their function through degrading mRNA or inhibiting protein translation.
Yingzhuang Song, Zhijing Xu, Fu Wang
doaj +1 more source
Environmental Health Perspectives, 2020 Background: High-throughput screening of chemicals with in vitro reporter gene assays in Tox21 has produced a large database on cytotoxicity and specific modes of action. However, the validity of some of the reported activities is questionable due to the
B. Escher +4 more
semanticscholar +1 more source
Biogenic Imaging Contrast Agents
Advanced Science, 2023 Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular ...
Qing Dan +4 more
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, 2009 Reporter gene assays are versatile and sensitive methods of assaying numerous targets in high-throughput drug-screening programs. A variety of reporter genes allow users a choice of signal that can be tailored to the required sensitivity, the available detection apparatus, the cellular system employed, and the required compatibility with multiplexed ...
Liu, A.M.F. +3 more
openaire +3 more sources
A reporter for noninvasively monitoring gene expression and plant transformation
Horticulture Research, 2020 Reporters have been widely used to visualize gene expression, protein localization, and other cellular activities, but the commonly used reporters require special equipment, expensive chemicals, or invasive treatments.
Yubing He +4 more
semanticscholar +1 more source
mBio, 2020 Dynamic changes in transcription profiles are key for the success of pathogens in colonizing their hosts. In many pathogens, genes associated with virulence, such as effector genes, are located in regions of the genome that are rich in transposable ...
Lukas Meile +5 more
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Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once. [PDF]
PLoS ONE, 2010 The molecular mechanisms regulating the activity of the TCRα gene are required for the production of the circulating T cell repertoire. Elements of the mouse TCRα locus control region (LCR) play a role in these processes. We previously reported that TCRα
Stefan Knirr +7 more
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Frontiers in Plant Science, 2022 A strawberry RIPK1, a leu-rich repeat receptor-like protein kinase, is previously demonstrated to be involved in fruit ripening as a positive regulator; however, its role in vegetable growth remains unknown.
Xuexue Chen +5 more
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Nature Communications, 2020 Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally characterized. Here we report an approach integrating massively-parallel reporter assays (MPRA) with cell-type-specific epigenome ...
Jiyeon Choi +26 more
semanticscholar +1 more source
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To establish a T-box transcription factor Brachyury (T gene) fluorescence reporter cell line, in which foot-and-mouth disease virus 2A (F2A) and enhanced green fluorescent protein (EGFP) were knocked in at the end of mouse T gene (mT-F2A-EGFP ...
WANG Jingyi, WANG Qiong
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