Results 31 to 40 of about 505,216 (312)

Optimizing RNA quality in cryopreserved tissues without preservatives: impact of preservatives, thawing methods and tissue aliquot sizes

BMC Biotechnology
Background RNA degradation during freeze‒thaw cycles in cryopreserved tissues is a major challenge for biomedical research, particularly when tissues are stored without preservatives.
Cong Zou, Mengxue Yu, Hongwei Peng, Xin Zhang, Zhao Deng, Zongning Zhou, Wenjing Li, Shanshan Zhang, Kaiyu Qian   +8 more
doaj   +1 more source

Virtual patients with cardiovascular pathology: technology for postgraduate medical education

Кардиоваскулярная терапия и профилактика, 2019
Aim. To develop an information basis for the formation and implementation of multimedia models for the diagnosis and treatment of depersonalized cases of cardiovascular diseases (virtual patients).Material and methods.
S. I. Karas, M. B. Arzhanik, A. E. Baev, V. Kh. Vaizov, O. Ya. Vasiltseva, E. V. Grakova, V. M. Gulyaev, K. V. Zavadovsky, E. E. Kara-Sal, W. Yu. Ussov   +9 more
doaj   +1 more source

Embracing the future: embedding digital repositories in the University of London [PDF]

, 2008
Digital repositories can help Higher Education Institutions (HEIs) to develop coherent and coordinated approaches to capture, identify, store and retrieve intellectual assets such as datasets, course material and research papers.
Hoorens, S., van Stolk, C., Villalba van Dijk, L.   +2 more
core  

Quality assurance for digital learning object repositories: issues for the metadata creation process [PDF]

, 2004
Metadata enables users to find the resources they require, therefore it is an important component of any digital learning object repository. Much work has already been done within the learning technology community to assure metadata quality, focused on ...
Barton, Jane, Currier, Sarah, O’Beirne, Rónán, Ryan, Ben   +3 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Repositories of Open Educational Resources: An Assessment of Reuse and Educational Aspects

International Review of Research in Open and Distributed Learning, 2017
This article provides an overview of the current state of repositories of open educational resources (ROER) in higher education at international level. It analyses a series of educational indicators to determine whether ROER can meet the specific needs ...
Gema Santos-Hermosa, Núria Ferran-Ferrer, Ernest Abadal   +2 more
doaj   +1 more source

Open Repositories 2012 [PDF]

, 2012
THE Open Repositories conference (OR) took place in Edinburgh in July, and showcased five days of the best the repository world has to offer. This year’s conference attracted 460 delegates from more than 40 countries, and once again showed the passion ...
Budden, Yvonne C.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Embracing the future: embedding digital repositories in the University of London. Briefing paper [PDF]

, 2009
This briefing paper captures the key findings and recommendations of a study commissioned by the Joint Information Systems Committee (JISC) on aspects of the strategic commitment of institutions to repository sustainability.1 This project, labelled ...
Hoorens, S., Villalba van Dijk, L.
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source