Results 231 to 240 of about 308,170 (360)

Enhanced biomass and desulfurization by recombinant Rhodococcus qingshengii IGTS8 in bioreactor cultures. [PDF]

Appl Microbiol Biotechnol
Martzoukou O, Breyanni D, Savvides AL, Karagouni AD, Mamma D, Hatzinikolaou DG.   +5 more
europepmc   +1 more source

Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments

Martina Begnis, Julien Duc, Sandra Offner, Delphine Grün, Shaoline Sheppard, Olga Rosspopoff, Didier Trono   +6 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

CTCF Regulates Erythroid Differentiation Through Control of Core Erythroid Transcription Factors. [PDF]

Biomolecules
García-Gaipo L, Junco V, García-Gutiérrez L, Torrano V, Blanco R, Wiesinger A, Pradeep R, Arroyo JL, Batlle-López A, León J, Rosa-Garrido M, Delgado MD.   +11 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multifaceted roles of miR‑124 in cancer: Molecular mechanisms and clinical prospects (Review). [PDF]

Int J Oncol
Guo J, Guo Y, Chen P, Xiao W, Tan Y, Wang Z, Lu Y, Yue X.   +7 more
europepmc   +1 more source

Reporter assay for local cis repression reveals Pvt1a and Pvt1b repressive activities.

Qiao Li (571252), Christiane E. Olivero (21864531), Erin Floyd (21864534), Jane Ding (14879057), Emily Dangelmaier (6331445), James Knight (3664885), Nadya Dimitrova (6579773)   +6 more
openalex   +1 more source

Polycomb repressive complex 2 impedes intestinal cell terminal differentiation

, 2012
Yannick D. Benoit, Manon Lepage, Taoufik Khalfaoui, Éric Tremblay, Nùria Basora, Julie Carrier, Lorraine J. Gudas, Jean‐François Beaulieu   +7 more
openalex   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Wake and break: deciphering the epigenetic regulation of dormancy onset and release in trees. [PDF]

Plant Cell
González-Suárez P.
europepmc   +1 more source