Results 241 to 250 of about 308,170 (360)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Neural stem cell quiescence is actively maintained by the epigenome. [PDF]

Cell Rep
Malkowska A, Ander J, Brand AH.
europepmc   +1 more source

Intercellular Delay Regulates the Collective Period of Repressively Coupled Gene Regulatory Oscillator Networks

, 2013
Yongqiang Wang, Yutaka Hori, Shinji Hara, Francis J. Doyle   +3 more
openalex   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Regulatory grammar in human promoters uncovered by MPRA-based deep learning. [PDF]

Nature
Barbadilla-Martínez L, Klaassen N, Franceschini-Santos VH, Breda J, Yücel H, Hernández-Quiles M, van Lieshout T, Urzua Traslaviña CG, Boi MCL, Akbarzadeh M, Hermana-Garcia-Agullo C, Gregoricchio S, de Haas M, Straver R, Derks S, Zwart W, Voest E, Franke L, Vermeulen M, de Ridder J, van Steensel B.   +20 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states. [PDF]

Nucleic Acids Res
Yang L, Liu S, Lu T, Mo S, Qi B, Yen K.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Roles of TIF1β in Leukemic Stem Cell Through SETDB1-Dependent and Independent Mechanisms. [PDF]

Cancer Sci
Morii M, Kubota S, Sashida G.
europepmc   +1 more source

SP140 represses specific loci by recruiting polycomb repressive complex 2 and NuRD complex [PDF]

Simone Tamburri, Chiara Zucchelli, Vittoria Matafora, Ettore Zapparoli, Ž Jevtić, Francesco Farris, Fabio Iannelli, Giovanna Musco, Angela Bachi   +8 more
openalex   +1 more source