Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states [PDF]
Nature CommunicationsNuclear receptors (NRs) are thought to dynamically alternate between transcriptionally active and repressive conformations, which are stabilized upon ligand binding.
Brian S. MacTavish +7 more
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Review essay: Disentangling feminisms from the cold war [PDF]
, 2020 Feminist thinkers have long argued for the centrality of sexuality, gender and women to the Cold War. They have critiqued the sexual language of ‘deep penetration’ and ‘orgasmic whumps’ used to describe nuclear arms race technology and argued that ...
Bellows-Blakely, Sarah
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Estrogen represses gene expression through reconfiguring chromatin structures [PDF]
Nucleic Acids Research, 2013 Estrogen regulates over a thousand genes, with an equal number of them being induced or repressed. The distinct mechanisms underlying these dual transcriptional effects remain largely unknown. We derived comprehensive views of the transcription machineries assembled at estrogen-responsive genes through integrating multiple types of genomic data. In the
Osmanbeyoglu, Hatice Ulku +6 more
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Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction
Structure, 2023 AbstractHeterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive.
Vladyslava Sokolova +11 more
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Penal practices of partisans in the Kaunas Region (1944–1952). Part II
Genocidas ir Rezistencija, 2021 Part 1 of this Article analyses campaigns of the partisans in Kaunas county and Kaunas city that took place in 1944-1945. Kaunas county geographically was a midpoint of Lithuania, it bordered the counties of Šakiai, Raseiniai, Kėdainiai, Ukmergė, Trakai
Gintautas Miknevičius
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Repression of IS200 transposase synthesis by RNA secondary structures [PDF]
Nucleic Acids Research, 1999 The IS 200 transposase, a 16 kDa polypeptide encoded by the single open reading frame (ORF) of the insertion element, has been identified using an expression system based on T7 RNA polymerase. In wild-type IS 200, two sets of internal inverted repeats that generate RNA secondary structures provide two independent mechanisms for repression of ...
Beuzón López, Carmen del Rosario +2 more
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Structural insight into glucose repression of the mannitol operon [PDF]
Scientific Reports, 2019 AbstractCarbon catabolite repression is a regulatory mechanism to ensure sequential utilization of carbohydrates and is usually accomplished by repression of genes for the transport and metabolism of less preferred carbon compounds by a more preferred one.
Mangyu Choe +5 more
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Structure, mechanism, and regulation of polycomb-repressive complex 2 [PDF]
Journal of Biological Chemistry, 2018 Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.
Lindsay E, Moritz, Raymond C, Trievel
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Canstatin represses glioma growth by inhibiting formation of VM-like structures [PDF]
Translational Neuroscience, 2021 Abstract Vasculogenic mimicry (VM) is different from classical tumor angiogenesis and does not depend on endothelial cells. VM is closely related to the prognosis of various cancers. Canstatin was first identified as an endogenous angiogenesis inhibitor.
Ma Yuqiang +8 more
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RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression [PDF]
Molecular and Cellular Biology, 2002 RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear matrix protein and identify structural determinants that target this protein to the ...
Tapan K, Chatterjee, Rory A, Fisher
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