Results 101 to 110 of about 136,304 (310)
A molecular switch regulating transcriptional repression and activation of PPARγ
Nature Communications, 2020 Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism.
Jinsai Shang +8 more
doaj +1 more source
The unfinished global revolution: intellectuals and the new politics of international relations [PDF]
, 2001 More than a decade after the revolutions of 1989, we can see these as a high point of a new, worldwide and increasingly global wave of democratic revolution and counter-revolution.
Shaw, Martin
core +2 more sources
DDX3 depletion selectively represses translation of structured mRNAs [PDF]
, 2019 DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Its yeast ortholog Ded1 controls the translation of nearly all mRNAs, whereas DDX3 is thought to regulate only a subset of mRNAs. However, the set of mRNAs that are regulated by DDX3 are unknown, along with the relationship between DDX3 binding and activity.
Calviello, Lorenzo +9 more
openaire +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
How to Analyze Islamist Politics: Is it possible to make a Political Study without Sociology of Islam? [PDF]
, 2018 This article embarks on making a political analysis of Islamist politics by criticizing the hegemonic approach in the field and considering a number of the institutions or structures, composing of either state and its ideological-repressive apparatuses ...
Erden, Ozgur Olgun
core
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]
, 2018 The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello +51 more
core +1 more source
Activation and repression of transcription initiation by a distant DNA structural transition [PDF]
Molecular Microbiology, 2001 Negative superhelical tension can drive local transitions to alternative DNA structures. Long regions of DNA may contain several sites that are susceptible to forming alternative structures. Their relative propensities to undergo transition are ordered according to the energies required for their formation.
S D, Sheridan, M L, Opel, G W, Hatfield
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The Evolving Landscape of Internet Control [PDF]
, 2011 Over the past two years, we have undertaken several studies at the Berkman Center designed to better understand the control of the Internet in less open societies.
Ethan Zuckerman +4 more
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source