Results 261 to 270 of about 491,654 (394)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Overexpression of AdeIJK RND efflux pump in <i>Acinetobacter baumannii</i> using the mini-Tn<i><b>7</b></i>T-based single copy induction system can lead to <i>lacI^q</i> mutation. [PDF]

Microbiol Spectr
Wimalasekara RL, Patidar R, White D, Kumar A.   +3 more
europepmc   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Reprogramming feedback strength in gibberellin biosynthesis highlights conditional regulation by the circadian clock and carbon dioxide. [PDF]

PLoS One
Leydon AR, Flores L, Khakhar A, Nemhauser JL.   +3 more
europepmc   +1 more source

LAC REPRESSOR

Biophysical Journal, 1980
Jarema, Mary Ann C., Lu, Ponzy, Miller, Jeffrey H.   +2 more
openaire   +1 more source

Rice JASMONIC ACID OXIDASES control resting jasmonate metabolism to promote growth and repress basal immune responses [PDF]

Simon Y. A. Ndecky, Ludivine Malherbe, Claire Villette, Véronique Chalvon, Isabelle Meusnier, Dennisse Beltran-Valencia, Nicolas Baumberger, Michael Riemann, Thomas Kroj, Antony Champion, Thierry Heitz   +10 more
openalex   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

All the world's a phage. [PDF]

Proc Natl Acad Sci U S A
Hatfull GF.
europepmc   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Rme1: Unveiling a Novel Repressor in the Cellulolytic Pathway of <i>Trichoderma reesei</i>. [PDF]

J Fungi (Basel)
Antoniêto ACC, Maués DB, Candido M, Taveira IC, Silva RN.   +4 more
europepmc   +1 more source