Results 301 to 310 of about 334,121 (353)

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Overexpression of <i>TCP5</i> or Its Dominant Repressor Form, <i>TCP5-SRDX</i>, Causes Male Infertility in Arabidopsis. [PDF]

Int J Mol Sci
Li T, Tian P, Wang X, Li M, Xing S.
europepmc   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Genome Sequences of the <i>Arthrobacter globiformis</i> Phage BillyTP (Cluster AY) and <i>Gordonia rubripertincta</i> Phage MAnor (Cluster CT). [PDF]

MicroPubl Biol
Melton J, Augustus C, Dotson J, Camara A, Christian L, McClendon D, Severson M, Wills M, Burris D, Williams D, Williams V, Ganguly S.   +11 more
europepmc   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

A cross-species inducible system for enhanced protein expression and multiplexed metabolic pathway fine-tuning in bacteria. [PDF]

Nucleic Acids Res
Li Y, Wu Y, Xu X, Liu Y, Li J, Du G, Lv X, Li Y, Liu L.   +8 more
europepmc   +1 more source

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

Advanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source

Capicua transcriptional repressor (CIC)-rearranged sarcoma harboring CIC-LEUTX fusion with renal involvement: a rare case report. [PDF]

Transl Cancer Res
Zhu J, Chen C, Li Y.
europepmc   +1 more source

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

Advanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng‐Ming (Spring) Kong, Gen Yang   +14 more
wiley   +1 more source

Primary capicua transcriptional repressor-rearranged sarcoma in the thyroid gland with cervical lymph node and lung metastases: a case report and literature review. [PDF]

Discov Oncol
Wang L, Liu W, Tang W, Ma Y, Liu XB, Liu F.   +5 more
europepmc   +1 more source