Results 31 to 40 of about 491,654 (394)

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Repressors of reprogramming

World Journal of Stem Cells, 2015
Induced pluripotent stem cells (iPSCs) have been the focal point of ever increasing interest and scrutiny as they hold the promise of personalized regenerative medicine. However, creation of iPSCs is an inefficient process that requires forced expression of potentially oncogenic proteins.
Melissa, Popowski, Haley, Tucker
openaire   +2 more sources

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Molecular Systems Biology, 2014
Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis ...
Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen   +16 more
doaj   +1 more source

CrgA Protein Represses AlkB2 Monooxygenase and Regulates the Degradation of Medium-to-Long-Chain n-Alkanes in Pseudomonas aeruginosa SJTD-1

Frontiers in Microbiology, 2019
AlkB monooxygenases in bacteria are responsible for the hydroxylation of medium- and long-chain n-alkanes. In this study, one CrgA protein of Pseudomonas aeruginosa SJTD-1, a member of LysR family, was proved to regulate AlkB2 monooxygenase and the ...
Nannan Ji, Xiuli Wang, Chong Yin, Wanli Peng, Rubing Liang   +4 more
doaj   +1 more source

Optimizing periodicity and polymodality in noise-induced genetic oscillators [PDF]

, 2011
Many cellular functions are based on the rhythmic organization of biological processes into self-repeating cascades of events. Some of these periodic processes, such as the cell cycles of several species, exhibit conspicuous irregularities in the form of
A. Sveiczer, E. M. Izhikevich, Gürol M. Süel, J. E. Rose, Jordi Garcia-Ojalvo, Pau Rué, U. Alon   +6 more
core   +3 more sources

The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor

Frontiers in Microbiology, 2018
Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import.
Stefanie Ronzheimer, Bianca Warmbold, Christian Arnhold, Erhard Bremer, Erhard Bremer   +4 more
doaj   +1 more source

What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]

, 2014
Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate ...
Berg, Johannes, Bhogale, Prasanna M., Sorg, Robin A., Veening, Jan-Willem   +3 more
core   +2 more sources

A 314-bp SINE insertion in the ZNF2 promoter region may act as a repressor related to regulation of fat deposition in pigs

Journal of Integrative Agriculture, 2023
Retrotransposons, a type of DNA fragment that can mobilize itself on genome, can generate genetic variations and develop for molecular markers based on the insertion polymorphism.
Hao GU, Zhan-yu DU, Eduard MURANI, Enrico D'ALESSANDRO, Cai CHEN, Xiao-yan WANG, Jiu-de MAO, Klaus WIMMERS, Cheng-yi SONG   +8 more
doaj   +1 more source

Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice

Frontiers in Plant Science, 2017
Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition ...
Zhigang Zheng, Xiaoming Yang, Yaping Fu, Longfei Zhu, Hantian Wei, Xinchun Lin   +5 more
doaj   +1 more source

Isolating intrinsic noise sources in a stochastic genetic switch [PDF]

, 2011
The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to
Newby, J. M.
core   +2 more sources