Results 41 to 50 of about 355,752 (283)

Finding the center reliably: robust patterns of developmental gene expression

, 2005
We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior.
A. Eldar, A. M. Turing, A. V. Spirov, B. Houchmandzadeh, C. Zhao, H. Meinhardt, L. Wolpert, Martin Howard, Pieter Rein ten Wolde, X. Ma   +9 more
core   +1 more source

Effect of promoter architecture on the cell-to-cell variability in gene expression [PDF]

, 2010
According to recent experimental evidence, the architecture of a promoter, defined as the number, strength and regulatory role of the operators that control the promoter, plays a major role in determining the level of cell-to-cell variability in gene ...
A Bar-Even, A Gansen, A Raj, A Raj, A Sanchez, A Singh, A Warmflash, AC Babic, AD Cameron, Alvaro Sanchez, B Muller-Hill, BS Burz, C Zurla, CD Cox, CD Cox, D Kennell, D Müller, D Nevozhay, D Zenklusen, Daniel Jones, DF Browning, DR Rigney, DT Gillespie, DW Austin, E Segal, EM Ozbudak, F Vanzi, F Vanzi, FMV Rossi, G Li, G Tkacik, H Boeger, H Maamar, HD Kim, HD Kim, Hernan G. Garcia, I Golding, IB Dodd, J Elf, J Gertz, J Müller, J Ou, J Paulsson, J Paulsson, J Peccoud, J Yu, Jané Kondev, JK Joung, JK Joung, JM Pedraza, JM Pedraza, JM Raser, JM Vilar, JM Vilar, JR Chubb, JS van Zon, K Gaston, KF Murphy, KS Koblan, L Bintu, L Bintu, L Cai, L Saiz, LS Weinberger, M Ackerman, M Dobrzynski, M Kaern, M Ptashne, M Shin, M Thattai, M Voliotis, MA Shea, MB Elowitz, MF Wernet, MJ Dunlop, N Maheshri, N Rosenfeld, NE Buchler, O Berg, OK Wong, PJ Choi, PJ Ingram, PJ Schlax, PS Gutierrez, PS Swain, R Losik, Rob Phillips, S Klumpp, S Semsey, SB Straney, SE Halford, T Höfer, T Kuhlman, T Raveh-Sadka, TB Kepler, TL To, TP Malan, TS Karpova, U Moran, V Shahrezaei, WJ Blake, WJ Blake, Wyeth W. Wasserman, Y Taniguchi, Y Wang   +104 more
core   +5 more sources

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

eLife, 2019
Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood.
Meredith A Sommars, Krithika Ramachandran, Madhavi D Senagolage, Christopher R Futtner, Derrik M Germain, Amanda L Allred, Yasuhiro Omura, Ilya R Bederman, Grant D Barish   +8 more
doaj   +1 more source

R2R3-MYB Transcription Factors Regulate Anthocyanin Biosynthesis in Grapevine Vegetative Tissues

Frontiers in Plant Science, 2020
Anthocyanins with important physiological functions mainly accumulate in grape berry, but teinturier grape cultivars can accumulate anthocyanins in both reproductive and vegetative tissues.
Sha Xie, Yujuan Lei, Huawei Chen, Junnan Li, Huangzhao Chen, Huangzhao Chen, Zhenwen Zhang, Zhenwen Zhang   +7 more
doaj   +1 more source

Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis

Plants, 2013
We produced transgenic Arabidopsis plants that express chimeric genes for transcription factors converted to dominant repressors, using Chimeric REpressor gene-Silencing Technology (CRES-T), and evaluated the salt tolerance of each line.
Daisuke Kazama, Masateru Itakura, Takamitsu Kurusu, Nobutaka Mitsuda, Masaru Ohme-Takagi, Yuichi Tada   +5 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression [PDF]

, 2008
Background Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance.
A Bar-Even, A Becskei, A de la Hoz, A Kierzek, C Cox, D Austin, Dafyd J Jenkins, Dov J Stekel, E Ozdubak, F Neidhardt, G Shinar, H El-Samad, I Keseler, J Paulsson, J Plumbridge, K Kostelidou, L Bingle, L Cai, M Elowitz, M Gibson, M Keeling, M Koern, M Samoilov, M Simpson, M Simpson, M Thattai, M Wall, N Rosenfeld, P Chivers, P Swain, Q Wang, R Rolfes, S Hooshangi, S Reichheld, T Kepler, Y Dublanche   +35 more
core   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Dynamic competition between transcription initiation and repression: Role of nonequilibrium steps in cell-to-cell heterogeneity

, 2015
Transcriptional repression may cause transcriptional noise by a competition between repressor and RNA polymerase binding. Although promoter activity is often governed by a single limiting step, we argue here that the size of the noise strongly depends on
Mitarai, Namiko, Semsey, Szabolcs, Sneppen, Kim   +2 more
core   +1 more source