Results 51 to 60 of about 496,166 (395)

NagRBt Is a Pleiotropic and Dual Transcriptional Regulator in Bacillus thuringiensis

Frontiers in Microbiology, 2018
NagR, belonging to the GntR/HutC family, is a negative regulator that directly represses the nagP and nagAB genes, which are involved in GlcNAc transport and utilization in Bacillus subtilis.
Zhang-lei Cao, Tong-tong Tan, Yan-li Zhang, Lu Han, Xiao-yue Hou, Hui-yong Ma, Jun Cai, Jun Cai, Jun Cai   +8 more
doaj   +1 more source

Diffusive hidden Markov model characterization of DNA looping dynamics in tethered particle experiments [PDF]

, 2007
In many biochemical processes, proteins bound to DNA at distant sites are brought into close proximity by loops in the underlying DNA. For example, the function of some gene-regulatory proteins depends on such DNA looping interactions.
Andrec M, Bevington P R, Colquhoun D, Cox D R, Gelles J, John F Beausang, Philip C Nelson, Press W H, Qian H, Qin F, Qin F, Smith D A, Wong O K Guthold M Erie D A Gelles J, Yin H, Zocchi G, Zurla C   +15 more
core   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Stochastic Gene Expression in Single Gene Oscillator Variants [PDF]

, 2016
It is infeasible to understand all dynamics in cell, but we can aim to understand the impact of design choices under our control. Here we consider a single gene oscillator as a case study to understand the influence of DNA copy number and repressor ...
Bennett, Matthew R., Gomez, Marcella M., Murray, Richard M., Shis, David L., Swaminathan, Anandh   +4 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Regulatory role of tetR gene in a novel gene cluster of Acidovorax avenae subsp. avenae RS-1 under oxidative stress

Frontiers in Microbiology, 2014
Acidovorax avenae subsp. avenae is the causal agent of bacterial brown stripe disease in rice. In this study, we characterized a novel horizontal transfer of a gene cluster, including tetR, on the chromosome of A. avenae subsp. avenae RS-1 by genome-wide
He eLiu, Chun-lan eYang, Meng-yu eGe, Muhammad eIbrahim, Bin eLi, Wen-jun eZhao, Gong-you eChen, Bo eZhu, Guan-lin eXie   +8 more
doaj   +1 more source

Compositionality, stochasticity and cooperativity in dynamic models of gene regulation

, 2007
We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a ``gene gate'' and defines an input/output-relationship corresponding to the binding and ...
Alberts B, Andrew Phillips, Blossey R, Bundschuh R, Cherry JL, De Jong H, Fall CP, Freidlin MI, Kim J, Lee Deville RE, Luca Cardelli, Milner R, Müller S, Phillips A, Priami C, Ralf Blossey, Smolen P, Thomas R, Thomas R, Van Kampen NG   +19 more
core   +2 more sources

Structure and function of negative feedback loops at the interface of genetic and metabolic networks [PDF]

, 2006
The molecular network in an organism consists of transcription/translation regulation, protein-protein interactions/modifications and a metabolic network, together forming a system that allows the cell to respond sensibly to the multiple signal molecules
Andersson, Anna M. C., Krishna, Sandeep, Semsey, Szabolcs, Sneppen, Kim   +3 more
core   +4 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source