Results 71 to 80 of about 264,694 (307)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Manipulation of gene expression using the 434 repressor.
, 1992 The interactions of the 434 repressor with its operator DNA have been extensively studied in vitro. The aims of the project described in this thesis have been to characterise the activity of the 434 repressor, the product of the coliphage 434 cl gene ...
Carl Innes. Webster (7676234)
core +3 more sources
Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
eLife, 2019 Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has
Emma J Gehrke +13 more
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity. [PDF]
FEBS Open BioWe identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Morea V +5 more
europepmc +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Site-directed mutagenesis of thelac repressor protein
, 1990 The lac repressor-lac operator is considered a model for procaryotic gene regulation. The specificity and strength of lac repressor-operator interactions is not completely understood.
Wisniowski, Paul Edward
core +1 more source
, 2011 An internal promoter drives expression of a truncated transcription factor that acts as a dominant-negative repressor of Wnt-responsive genes.
Annalisa M. VanHook
core +1 more source
Half-of-the-sites reactivity of F235C λ-repressor: implications for the structure of the whole repressor [PDF]
, 2002 A site-directed mutation, F235C, was created at the penultimate residue of the λ-repressor. Measurement of dimer–monomer dissociation constant suggested that dimer–monomer dissociation of the mutant repressor is similar to that of the wild-type. Affinity
Bandyopadhyay, Sumita +7 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance
, 1994 The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance ...
Hillen, W. +15 more
core +1 more source