Results 91 to 100 of about 483,350 (345)

Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression [PDF]

, 2011
It has been shown in several organisms that multiple cis-regulatory modules (CRMs) of a gene locus can be active concurrently to support similar spatiotemporal expression.
Dunipace, Leslie, Ozdemir, Anil, Stathopoulos, Angelike   +2 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition

Journal of Cell Biology, 1996
We report a new method for in situ localization of DNA sequences that allows excellent preservation of nuclear and chromosomal ultrastructure and direct, in vivo observations.
C. C. Robinett, A. Straight, Gang Li, C. Willhelm, G. Sudlow, A. Murray, A. Belmont   +6 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Subspecialization of R2R3-MYB repressors for anthocyanin and proanthocyanidin regulation in forage legumes

Frontiers in Plant Science, 2015
The synthesis of anthocyanin pigments and proanthocyanidins (condensed tannins) is regulated by MYB-bHLH-WDR (MBW) transcription factor complexes in all angiosperms studied to date. Tr-MYB133 and Tr-MYB134 were isolated from T.
Nick W Albert, Nick W Albert
doaj   +1 more source

A Master equation approach to modeling an artificial protein motor

, 2010
Linear bio-molecular motors move unidirectionally along a track by coordinating several different processes, such as fuel (ATP) capture, hydrolysis, conformational changes, binding and unbinding from a track, and center-of-mass diffusion.
Alberts, Allen, Astumian, Astumian, Astumian, Astumian, Balzani, Bath, Borden, Bromley, Bustamante, Carey, Craig, Eaton, Feringa, Finucane, Geertsema, Gerhard A. Blab, Greenleaf, Heiner Linke, Howard, Kay, Klok, Kottas, Magnasco, Nathan J. Kuwada, Parsons, Phillips, Schaad, Silvi, Stockley, van Delden, Vilfan, Vilfan, Wang, Yurke   +35 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The evolution of Bordetella pertussis has selected for mutations of acr that lead to sensitivity to hydrophobic molecules and fatty acids

Emerging Microbes and Infections, 2019
Whooping cough, or pertussis, is resurgent in numerous countries worldwide. This has renewed interest in Bordetella pertussis biology and vaccinology. The in vitro growth of B. pertussis has been a source of difficulty, both for the study of the organism
Iain MacArthur, Thomas Belcher, Jerry D. King, Vasantha Ramasamy, Munirah Alhammadi, Andrew Preston   +5 more
doaj   +1 more source

Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues

Nature Communications, 2013
The developmental transition to flowering is timed by endogenous and environmental signals through multiple genetic pathways. In Arabidopsis, the MADS-domain protein FLOWERING LOCUS C is a potent flowering repressor.
X. Gu, C. Le, Yizhong Wang, Zicong Li, Danhua Jiang, Yuqi Wang, Yuehui He   +6 more
semanticscholar   +1 more source