Results 91 to 100 of about 264,694 (307)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Translational control by G-quadruplex recognition via REPRESSOR OF PHLOEM DEVELOPMENT determines differentiation of energy transducing vascular tissue in plants

, 2017
Translational control by G-quadruplex recognition via REPRESSOR OF PHLOEM DEVELOPMENT determines differentiation of energy transducing vascular tissue in ...
HWANG, ILDOO
core  

GFI1B (growth factor independent 1B transcription repressor) [PDF]

, 2011
Review on GFI1B (growth factor independent 1B transcription repressor), with data on DNA, on the protein encoded, and where the gene is ...
T Möröy, Möröy, T, L Vassen, Vassen, L   +3 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Separation of transcriptional repressor and activator functions in HDAC3

, 2022
The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex and its canonical function is in transcriptional repression, but it can also activate transcription.
Liu, X, Xu, L, Regadas, I, Belikov, S, Shilkova, O, Wernersson, E, Wu, H, Bienko, M,, Tang, M, Mannervik, M   +9 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

GFI1 (growth factor independent 1 transcription repressor) [PDF]

, 2011
Review on GFI1 (growth factor independent 1 transcription repressor), with data on DNA, on the protein encoded, and where the gene is ...
Möröy, T, Khandanpour, C
core   +1 more source

PtoHsfB1 regulates growth and salt response by affecting ABA biosynthesis in Populus tomentosa

Forestry Research
Poplar is an important commercial timber species and a model organism for forest molecular biology. Here, we identified PtoHsfB1, a subgroup B heat shock transcription factor from Populus tomentosa that is homologous to AtHsfB1 and PtrHsfB1, and contains
Kunjin Han, Huayu Si, Ye Li, Jifeng Yan, Yousry A. El-Kassaby, Yizhe Cheng, Houyin Deng, Jie Liu, Yuhan Sun, Yun Li, Ye Zhao   +10 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage

Viruses, 2013
In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj, Michael P. Colon, Gerald B. Koudelka   +2 more
doaj   +1 more source