Results 61 to 70 of about 382,695 (354)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

TCPs, WUSs, and WINDs: Families of transcription factors that regulate shoot meristem formation, stem cell maintenance, and somatic cell differentiation

Frontiers in Plant Science, 2014
In contrast to somatic mammalian cells, which cannot alter their fate, plant cells can dedifferentiate to form totipotent callus cells and regenerate a whole plant, following treatment with specific phytohormones.
Miho eIkeda, Masaru eOhme-Takagi, Masaru eOhme-Takagi   +2 more
doaj   +1 more source

The transcriptional repressor domain of Gli3 is intrinsically disordered. [PDF]

PLoS ONE, 2013
The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway. Gli3 contains a repressor domain in its N-terminus from residue G106 to E236.
Robert Tsanev, Kalju Vanatalu, Jüri Jarvet, Risto Tanner, Kristi Laur, Piret Tiigimägi, Birthe B Kragelund, Torben Østerlund, Priit Kogerman   +8 more
doaj   +1 more source

Regulatory control and the costs and benefits of biochemical noise [PDF]

, 2008
Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells, is, however, a wide open question.
A Bar-Even, A Becskei, A Sigal, A Wagner, Aviv Regev, DM Wolf, DS Falconer, DT Gillespie, DW Austin, E Dekel, E Dekel, E Kussell, E Kussell, E Levine, E Ziv, EM Ozbudak, G Yagil, H Risken, J Elf, J Paulsson, J Seger, J Yu, JL Ingraham, JM Pedraza, JM Raser, JR Sadler, JRS Newman, L Cai, M Kaern, M Thattai, MA Savageau, MA Savageau, MB Elowitz, MB Elowitz, MW van der Woude, N Rosenfeld, NQ Balaban, P Kolkhof, PB Detwiler, Pieter Rein ten Wolde, S Gavrilets, S Tănase-Nicola, Sorin Tănase-Nicola, T Kalisky, T Lu, T Shibata, W Gilbert, X Zhang   +47 more
core   +5 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Rules for biological regulation based on error minimization

, 2006
The control of gene expression involves complex mechanisms that show large variation in design. For example, genes can be turned on either by the binding of an activator (positive control) or the unbinding of a repressor (negative control).
Atkinson, Becskei, Blake, Collado-Vides, Dekel, E. Dekel, Elena, Elowitz, Elowitz, G. Shinar, Gardner, Guet, Hartl, Hasty, Ibarra, Kaern, Martinez-Pastor, McAdams, McAdams, Nguyen, Ochman, Ozbudak, Paulsson, Pedraza, Postma, Rabin, Rosenfeld, Savageau, Savageau, Savageau, Savageau, Savageau, Sengupta, Skerker, Sprinzak, T. Tlusty, U. Alon, Zarrinpar   +37 more
core   +2 more sources

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Mutzel, V., Schulz, E.
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis

Plants, 2013
We produced transgenic Arabidopsis plants that express chimeric genes for transcription factors converted to dominant repressors, using Chimeric REpressor gene-Silencing Technology (CRES-T), and evaluated the salt tolerance of each line.
Daisuke Kazama, Masateru Itakura, Takamitsu Kurusu, Nobutaka Mitsuda, Masaru Ohme-Takagi, Yuichi Tada   +5 more
doaj   +1 more source

Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]

PLoS ONE, 2013
The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla, Michael A Grosner, David Swigon, Wilma K Olson   +3 more
doaj   +1 more source