Results 61 to 70 of about 491,654 (394)

ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence.
Benga, L., Fulde, M., Goethe, R., Greeff, A., de, Smith, H.E., Valentin-Weigand, P., Willenborg, J.   +6 more
core   +2 more sources

Lac repressor at last [PDF]

Structure, 1996
Crystal and cocrystal structures of the LacI and PurR repressors reveal a novel use of hinge alpha helices which bind in the minor groove of the operator and mediate transmission of the allosteric signals that modulate DNA-binding activity.
openaire   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

eLife, 2019
Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood.
Meredith A Sommars, Krithika Ramachandran, Madhavi D Senagolage, Christopher R Futtner, Derrik M Germain, Amanda L Allred, Yasuhiro Omura, Ilya R Bederman, Grant D Barish   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

TCPs, WUSs, and WINDs: Families of transcription factors that regulate shoot meristem formation, stem cell maintenance, and somatic cell differentiation

Frontiers in Plant Science, 2014
In contrast to somatic mammalian cells, which cannot alter their fate, plant cells can dedifferentiate to form totipotent callus cells and regenerate a whole plant, following treatment with specific phytohormones.
Miho eIkeda, Masaru eOhme-Takagi, Masaru eOhme-Takagi   +2 more
doaj   +1 more source

The transcriptional repressor domain of Gli3 is intrinsically disordered. [PDF]

PLoS ONE, 2013
The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway. Gli3 contains a repressor domain in its N-terminus from residue G106 to E236.
Robert Tsanev, Kalju Vanatalu, Jüri Jarvet, Risto Tanner, Kristi Laur, Piret Tiigimägi, Birthe B Kragelund, Torben Østerlund, Priit Kogerman   +8 more
doaj   +1 more source

Regulatory control and the costs and benefits of biochemical noise [PDF]

, 2008
Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells, is, however, a wide open question.
A Bar-Even, A Becskei, A Sigal, A Wagner, Aviv Regev, DM Wolf, DS Falconer, DT Gillespie, DW Austin, E Dekel, E Dekel, E Kussell, E Kussell, E Levine, E Ziv, EM Ozbudak, G Yagil, H Risken, J Elf, J Paulsson, J Seger, J Yu, JL Ingraham, JM Pedraza, JM Raser, JR Sadler, JRS Newman, L Cai, M Kaern, M Thattai, MA Savageau, MA Savageau, MB Elowitz, MB Elowitz, MW van der Woude, N Rosenfeld, NQ Balaban, P Kolkhof, PB Detwiler, Pieter Rein ten Wolde, S Gavrilets, S Tănase-Nicola, Sorin Tănase-Nicola, T Kalisky, T Lu, T Shibata, W Gilbert, X Zhang   +47 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source