Results 81 to 90 of about 496,166 (395)

Rules for biological regulation based on error minimization

, 2006
The control of gene expression involves complex mechanisms that show large variation in design. For example, genes can be turned on either by the binding of an activator (positive control) or the unbinding of a repressor (negative control).
Atkinson, Becskei, Blake, Collado-Vides, Dekel, E. Dekel, Elena, Elowitz, Elowitz, G. Shinar, Gardner, Guet, Hartl, Hasty, Ibarra, Kaern, Martinez-Pastor, McAdams, McAdams, Nguyen, Ochman, Ozbudak, Paulsson, Pedraza, Postma, Rabin, Rosenfeld, Savageau, Savageau, Savageau, Savageau, Savageau, Sengupta, Skerker, Sprinzak, T. Tlusty, U. Alon, Zarrinpar   +37 more
core   +2 more sources

Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]

, 2008
We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis, Davidson, Dawson, E. H. Davidson, Fisher, Giagtzoglou, Gyory, Howard-Ashby, Howard-Ashby, J. Smith, Kuo, Lee, Livi, Materna, McClay, Minokawa, Oellers, Oliveri, Osipovich, Peterson, Ransick, Revilla-i-Domingo, Rizzo, Robertson, Sea Urchin Genome Sequencing Consortium, Sherwood, Smith, Smith, Thirunavukkarasu, Tietze, Tu, Walton, Wikramanayake, Yu, Yuh   +34 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Increased skin conductance responses and neural activity during fear conditioning are associated with a repressive coping style

Frontiers in Behavioral Neuroscience, 2015
The investigation of individual differences in coping styles in response to fear conditioning is an important issue for a better understanding of the etiology and treatment of psychiatric disorders.
Tim eKlucken, Onno eKruse, Jan eSchweckendiek, Rudolf eStark   +3 more
doaj   +1 more source

The lac repressor

Comptes Rendus. Biologies, 2005
Few proteins have had such a strong impact on a field as the lac repressor has had in Molecular Biology. Over 40 years ago, Jacob and Monod [Genetic regulatory mechanisms in the synthesis of proteins, J. Mol. Biol. 3 (1961) 318] proposed a model for gene regulation, which survives essentially
openaire   +2 more sources

Lateral Gene Expression in Drosophila Early Embryos Is Supported by Grainyhead-Mediated Activation and Tiers of Dorsally-Localized Repression [PDF]

, 2011
The general consensus in the field is that limiting amounts of the transcription factor Dorsal establish dorsal boundaries of genes expressed along the dorsal-ventral (DV) axis of early Drosophila embryos, while repressors establish ventral boundaries ...
A Jazwinska, A Ozdemir, A Stathopoulos, A Stathopoulos, Angelike Stathopoulos, B Adryan, B Biehs, B Schnepp, BD Dynlacht, BJ Rutledge, C Ghiglione, C Lanzuolo, C Mizutani, C Nusslein-Volhard, C Rushlow, Christos Samakovlis, D Kosman, D Stein, DH Huang, E Bier, E Ferguson, E Zandi, F Jimenez, G Jimenez, G Pyrowolakis, GJ Liaw, GT Reeves, H Chu, H Dai, H Lee, H-L Liang, HJ Doyle, J Cowden, J Huang, J Jiang, J Jiang, J Jiang, J Kadonaga, JB Weiss, JW Hodgson, K Arora, K Staehling-Hampton, L Ajuria, LM Liberman, LM Liberman, M Grillo, M Kim, Mayra Garcia, MM Harrison, N Perrimon, NC Grieder, R Cornell, RP Ray, S Luschnig, S Small, S Urban, S Wang, SJ Bray, T Isshiki, T Von Ohlen, U Weber, V Morel, YT Ip, YT Ip   +63 more
core   +5 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

eLife, 2019
Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has
Emma J Gehrke, Xiafei Zhang, Sheila M Pimentel-Elardo, Andrew R Johnson, Christiaan A Rees, Stephanie E Jones, Hindra, Sebastian S Gehrke, Sonya Turvey, Suzanne Boursalie, Jane E Hill, Erin E Carlson, Justin R Nodwell, Marie A Elliot   +13 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A quantitative comparison of sRNA-based and protein-based gene regulation [PDF]

, 2008
Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression.
Berg HC, Ned S Wingreen, Pankaj Mehta, Ptashne M, Sidhartha Goyal, van Kampen NG   +5 more
core   +3 more sources