Results 81 to 90 of about 334,121 (353)
The Repressor-Lattice: Feed-Back, Commensurability, and Dynamical Frustration [PDF]
Phys. Rev. Lett. 103, 118101 (2009), 2009 A repressilator consists of a loop made up of three repressively interacting genes. We construct a hexagonal lattice with repressilators on each triangle, and use this as a model system for multiple interacting feedback loops. Using symmetry arguments and stability analysis we argue that the repressor-lattice can be in a non-frustrated oscillating ...
arxiv +1 more source
, 2015 Transcriptional repression may cause transcriptional noise by a competition between repressor and RNA polymerase binding. Although promoter activity is often governed by a single limiting step, we argue here that the size of the noise strongly depends on
Mitarai, Namiko +2 more
core +1 more source
Engineering orthogonal dual transcription factors for multi-input synthetic promoters [PDF]
, 2016 Synthetic biology has seen an explosive growth in the capability of engineering artificial gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial networks still employ the same core set of TFs (for example LacI,
Broedel, AK, Isalan, M, Jaramillo, A
core +2 more sources
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
eLife, 2019 Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has
Emma J Gehrke +13 more
doaj +1 more source
The N-terminal domain of the repressor of Staphylococcus aureus phage Φ11 possesses an unusual dimerization ability and DNA binding affinity. [PDF]
PLoS ONE, 2014 Bacteriophage Φ11 uses Staphylococcus aureus as its host and, like lambdoid phages, harbors three homologous operators in between its two divergently oriented repressor genes. None of the repressors of Φ11, however, showed binding to all three operators,
Anindya Biswas +2 more
doaj +1 more source
Modulation of DNA loop lifetimes by the free energy of loop formation [PDF]
PNAS 111 (49), 17396-17401 (2014), 2015 Storage and retrieval of the genetic information in cells is a dynamic process that requires the DNA to undergo dramatic structural rearrangements. DNA looping is a prominent example of such a structural rearrangement that is essential for transcriptional regulation in both prokaryotes and eukaryotes, and the speed of such regulations affects the ...
arxiv +1 more source
Binding of the Bacillus subtilis LexA protein to the SOS operator [PDF]
, 2005 The Bacillus subtilis LexA protein represses the SOS response to DNA damage by binding as a dimer to the consensus operator sequence 5′-CGAACN(4)GTTCG-3′.
Banky, Poopak +12 more
core +3 more sources
The C repressor of the P2 bacteriophage [PDF]
Journal of Biomolecular NMR, 2015 Version of ...
Tariq Massad +5 more
openaire +4 more sources
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source