Results 81 to 90 of about 1,879,235 (344)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Spatial transcriptomics identifies candidate stromal drivers of benign prostatic hyperplasia
JCI InsightBenign prostatic hyperplasia (BPH) is the nodular proliferation of the prostate transition zone in older men, leading to urinary storage and voiding problems that can be recalcitrant to therapy.
Anna S. Pollack +9 more
doaj +1 more source
Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort
JCI Insight, 2021 The syndrome of spontaneous preterm birth (sPTB) presents a challenge to mechanistic understanding, effective risk stratification, and clinical management.
Flavia Flaviani +13 more
doaj +1 more source
Biology, economy and reproduction [PDF]
Acta Obstetricia et Gynecologica Scandinavica, 2007 Economic theories have been used to explain fertility patterns 1, 2. Reduced fertility in the Western world has been explained by changes in women's investment from child bearing to education and p...
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Journal of Clinical Investigation, 2022 To understand how kidney donation leads to an increased risk of preeclampsia, we studied pregnant outbred mice with prior uninephrectomy and compared them with sham-operated littermates carrying both kidneys.
Vincent Dupont +10 more
doaj +1 more source
Apoptosis in reproductive biology [PDF]
Cell Death & Differentiation, 1997 Recent studies aimed at a greater understanding of the occurrence and regulation of cell death in reproductive biology provide a promising new direction for novel approaches to understanding normal and pathological aspects of reproduction. Several instances of physiologically occurring cell death (programmed cell death, PCD), associated with ...
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Short-term Western-style diet negatively impacts reproductive outcomes in primates
JCI Insight, 2021 A maternal Western-style diet (WSD) is associated with poor reproductive outcomes, but whether this is from the diet itself or underlying metabolic dysfunction is unknown.
Sweta Ravisankar +9 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source