Results 51 to 60 of about 743,359 (233)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Genetic links between post-reproductive lifespan and family size in Framingham. [PDF]

, 2013
BACKGROUND AND OBJECTIVES: Is there a trade-off between children ever born (CEB) and post-reproductive lifespan in humans? Here, we report a comprehensive analysis of reproductive trade-offs in the Framingham Heart Study (FHS) dataset using phenotypic ...
Wang, X, Byars, SG, Stearns, SC
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Maternal time interval between menarche and childbirth is associated with daughter's age at menarche

Acta Obstetricia et Gynecologica Scandinavica
Introduction Women's reproductive lifespan has increased over the past two decades. Simultaneously, female reproductive behavior has changed, with increasing age at first birth.
Mari Landås Warp, Thea Grindstad, Karoline H. Skåra, Maria C. Magnus, Siri E. Håberg, Nils‐Halvdan Morken, Liv Bente Romundstad, Cecilia H. Ramlau‐Hansen, Hans Ivar Hanevik   +8 more
doaj   +1 more source

Lifespan and reproductive data for temperature and sexual conflict level treatments

, 2019
Lifespan and reproductive data for temperature and sexual conflict level ...
Chirinos, Valeria, Pau Carazo (3200364), Carazo, Pau, Roberto Garcia-Roa (4817919), Valeria Chirinos (6186926), Garcia-Roa, Roberto   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Survival to reproductive cessation drives variation in post-reproductive lifespan

, 2014
How many post-reproductive individuals are found in a population depends on how many individuals survive to reproductive cessation and how long they live thereafter. Post-reproductive Representation (PrR), a measure of post-reproductive lifespan intended
Burger, Oskar, Levitis, Daniel, Proske, Beate   +2 more
core   +1 more source

No effect of partner age and lifespan on female age‐specific reproductive performance in blue tits [PDF]

, 2017
Amininasab SM, Hammers M, Vedder O, Komdeur J, Korsten P. No effect of partner age and lifespan on female age-specific reproductive performance in blue tits. Journal of Avian Biology.
Vedder, Oscar, Amininasab, Seyed Mehdi, Komdeur, Jan, Korsten, Peter ; https://orcid.org/, Hammers, Martijn, Korsten, Peter   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reproductive lifespan and age of first reproduction

, 2013
Abbreviations: BirdID = individual identifier; LayYear = year of birth; AFR = age of first reproduction as a dominant; RLS = reproductive lifespan; event = whether an individual died before the end of the study period; NatalGS = natal group size; NatalYQ
Richardson, David S., Martijn Hammers (316793), David S. Richardson (199136), Terry Burke (80052), Komdeur, Jan, Jan Komdeur (199135), Hammers, Martijn, Burke, Terry   +7 more
core   +1 more source