Results 71 to 80 of about 743,359 (233)

Datasets for analysis of nestlings sex, lifetime sex ratio of females and males, lifetime reproductive success, reproductive lifespan (longevity) and mortality of nestlings.

, 2015
Datasets for analysis of nestlings sex, lifetime sex ratio of females and males, lifetime reproductive success, reproductive lifespan (longevity) and mortality of nestlings.
Cor Dijkstra (151460), Nayden Chakarov (359051), Astrid Potiek (804406), Anna-Katharina Mueller (804405), Thomas Grünkorn (804407), Oliver Krüger (359052), Martina Pauli (804404)   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sex differences in the genetic architecture of lifespan in a seed beetle: extreme inbreeding extends male lifespan

BMC Evolutionary Biology, 2009
Background Sex differences in lifespan are ubiquitous throughout the animal kingdom but the causes underlying this phenomenon remain poorly understood. Several explanations based on asymmetrical inheritance patterns (sex chromosomes or mitochondrial DNA)
Maklakov Alexei A, Bilde Trine, Meisner Katrine, la Guardia Lucia, Friberg Urban   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Summary of the Total Lifespan of Guppies, Reported Separately for Each Drainage × Predation Combination

, 2013
The timeline reports the mean age at first reproduction, mean age at last reproduction (mean age at first reproduction plus mean reproductive lifespan), and total lifespan (mean age at first reproduction plus mean reproductive lifespan plus median post ...
Michael Bryant (27485), David Reznick (27484), Donna Holmes (27486)   +2 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Artificial selection for increased reproductive effort accelerates actuarial senescence and reduces lifespan in a precocial bird [PDF]

Life-history theory and evolutionary theories of ageing predict that trade-offs between reproduction and somatic maintenance shape the evolution of ageing and lifespan.
Joel L Pick (3397544), Barbara Tschirren (21065399), Erik Postma (21061721), Dave Hudson (21065045), Oscar Vedder (431732), Ana Angela Romero Haro (3315453)   +5 more
core   +4 more sources

Lifespan

, 2018
Lifespan of workers and soldiers for each nest (until all the individuals in the artificial diet treatment are ...
Arganda, Sara, Dussutour, Audrey, Laure-Anne Poissonnier (659798), Poissonnier, Laure-Anne, Jerome Buhl (145762), Buhl, Jerome, Simpson, Stephen (Steve), Stephen (Steve) Simpson (5672795), Sara Arganda (3596426), Audrey Dussutour (659799)   +9 more
core   +2 more sources