Results 91 to 100 of about 223,319 (331)

Potential adverse effects of nanoparticles on the reproductive system

International Journal of Nanomedicine, 2018
Ruolan Wang,1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3 1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Guizhou Provincial People’s Hospital, Guiyang 550002, China; 3Guangdong Provincial Key ...
Wang R, Song B, Wu J, Zhang Y, Chen A, Shao LQ   +5 more
doaj  

Nanoplastics and chain-length-dependent PFCs disrupt reproductive endocrinology by targeting the PKC - GnRH signaling axis

Ecotoxicology and Environmental Safety
Nanoplastics (NPs) and microplastics (MPs) are widespread in aquatic ecosystems and frequently co-occurred with perfluorinated compounds (PFCs), yet their combined toxic effects remain poorly understood.
Xi Li, Yuying Fang, Jinxi Song, Haichao Sha, Le Zhang, Qi Li   +5 more
doaj   +1 more source

Reproductive toxicity of benzophenone-3 [PDF]

Archives of Toxicology, 2020
Balmer NV, Klima S, Rempel E et al (2014) From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol 88(7):1451–1468.
openaire   +2 more sources

Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]

, 2017
In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita, Brooks, George A, Efe, Gizem, Garan, Steven A, Gouw, Arvin M, Mehdizadeh, Morvarid, Preecha, Andrew   +6 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Molecular Research on Reproductive Toxicity

International Journal of Molecular Sciences, 2023
Fertility rates in animals have shown a progressive decrease in recent decades, and reproductive toxicity is considered an important regulatory endpoint in health hazard assessment [...]
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective

Journal of Pharmaceutical Analysis
Microplastics and nanoplastics (MPs/NPs) are ubiquitous environmental pollutants that act as endocrine-disrupting chemicals (EDCs), raising significant concerns about their impact on human health.
Jiaojiao Zhang, Wenyi Liu, Fuqiang Cui, Marjukka Kolehmainen, Jing Chen, Lei Zhang, Iman Zarei   +6 more
doaj   +1 more source

Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins [PDF]

, 2000
PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and
Aguilar, A, Borrell, A, Haraguchi, K, Mattson, M, Siebert, U, Troisi, GM   +5 more
core  

Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]

, 2019
© 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos, Blasco Gutiérrez, Víctor, Martínez Jerónimo, Fernando, Moreno-Noguer, Francesc, Pestana, Joao, Porta Pleite, Josep Maria, Raldúa Pérez, Demetrio José, Simão, Fátima C.P., Soarez, Amadeu   +8 more
core   +1 more source