Results 1 to 10 of about 169,054 (174)
Cell & Bioscience, 2023 Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress cellular processes and is a key mediator in multiple organs.
Tingjun Liu +7 more
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Nature Communications, 2021 Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
Kay Oliver Schink +9 more
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Scientific Reports, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico +6 more
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Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview
Frontiers in Cell and Developmental Biology, 2023 The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is widely expressed in the central and peripheral nervous systems. This receptor is implicated in both brain development and adult neurogenesis thanks to its ability to mediate ...
Angela Maria Giada Giovenale +11 more
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ATPase activity of DFCP1 controls selective autophagy
Nature Communications, 2023 Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER)
Viola Nähse +11 more
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Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Pharmacology Research & Perspectives, 2022 CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama +5 more
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Cellular internalization effect of Ara27 in various cell lines
Journal of Animal Reproduction and Biotechnology, 2022 Protein and peptide candidates are screened to apply therapeutic application as a drug. Ensuring that these candidates are delivered and maximized effectiveness is still challenging and a variety of studies are ongoing.
Minseo Kim +3 more
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Scientific Reports, 2022 Drosophila melanogaster tumor models are growing in popularity, driven by the high degree of genetic as well as functional conservation to humans. The most common method to measure the effects of a tumor on distant organs of a human cancer patient is to ...
Petter Holland +4 more
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Human Neural Stem Cells for Cell-Based Medicinal Products
Cells, 2021 Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders.
Beatriz Fernandez-Muñoz +3 more
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Marker and source-marker reprogramming of Most Permissive Boolean networks and ensembles with BoNesis [PDF]
Peer Community Journal, 2023, 2022 Boolean networks (BNs) are discrete dynamical systems with applications to the modeling of cellular behaviors. In this paper, we demonstrate how the software BoNesis can be employed to exhaustively identify combinations of perturbations which enforce properties on their fixed points and attractors. We consider marker properties, which specify that some
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