Results 1 to 10 of about 376,055 (402)
Cellular decision-making bias: the missing ingredient in cell functional diversity [PDF]
arXiv, 2013 Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work. Using the metaphor of information processing and decision-making might provide a clearer view of these subtleties.
Alicea, Bradly
arxiv +4 more sources
An Algorithm for Cellular Reprogramming [PDF]
Proceedings of the National Academy of Sciences, 2017 The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away.
Bloch, Anthony +7 more
core +4 more sources
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation [PDF]
, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential to the reprogramming of cells for biomedical applications, i.e., the experimental recovery of ...
Furusawa, Chikara +2 more
arxiv +5 more sources
Cell Cycle, 2004 The diversity of activators and targets of the NF-kappaB transcription factor family demands that there be regulatory mechanisms in place to control the specificity with which genes under their control are induced. In part this can be achieved through selective induction of different NF-kappaB subunits and through co-operative interactions with ...
Kirsteen J. Campbell, Neil D. Perkins
openalex +3 more sources
The Journal of Cell Biology, 2004 Does the Kaposi sarcoma (KS) herpesvirus (KSHV) replicate in lymphatic endothelial cells (LECs) or blood vascular endothelial cells (BECs)? Two groups have come up with a surprising answer to this question: neither. Instead the oncogenic virus modifies both of the two cell types to an intermediate state that better suits the virus' replicative needs.
William A. Wells
openalex +4 more sources
"Nuclear Reprogramming" and "Epigenetic Reprogramming"
Journal of Mammalian Ova Research, 2004 Takashi Tada +2 more
openalex +4 more sources
Macrophage reprogramming for therapy [PDF]
Immunology, 2021 SummaryDysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent
Natacha Ipseiz +4 more
openaire +3 more sources
Cell & Bioscience, 2023 Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress cellular processes and is a key mediator in multiple organs.
Tingjun Liu +7 more
doaj +1 more source
Nature Communications, 2021 Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
Kay Oliver Schink +9 more
doaj +1 more source
Scientific Reports, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico +6 more
doaj +1 more source