Results 11 to 20 of about 205,281 (308)
Advances in Neural Information Processing Systems 35, 2022 Despite a surge of recent advances in promoting machine Learning (ML) fairness, the existing mainstream approaches mostly require retraining or finetuning the entire weights of the neural network to meet the fairness criteria. However, this is often infeasible in practice for those large-scale trained models due to large computational and storage costs,
Guanhua Zhang +6 more
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Cell & Bioscience, 2023 Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress cellular processes and is a key mediator in multiple organs.
Tingjun Liu +7 more
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ATPase activity of DFCP1 controls selective autophagy
Nature Communications, 2023 Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER)
Viola Nähse +11 more
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Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
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Development, 2013 There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the
Halley-Stott, Richard P. +2 more
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Nature Communications, 2021 Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
Kay Oliver Schink +9 more
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Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview
Frontiers in Cell and Developmental Biology, 2023 The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is widely expressed in the central and peripheral nervous systems. This receptor is implicated in both brain development and adult neurogenesis thanks to its ability to mediate ...
Angela Maria Giada Giovenale +11 more
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Scientific Reports, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico +6 more
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Fission for reprogramming [PDF]
Cell Cycle, 2016 The OSKM (Oct3/4, Sox2, Klf4, and c-Myc) factors trigger a complex array of signals that promote the reprogramming of somatic cells.
Juan Pablo Muñoz, Antonio Zorzano
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Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Pharmacology Research & Perspectives, 2022 CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama +5 more
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