Results 91 to 100 of about 403,028 (282)
Lost in translation: pluripotent stem cell‐derived hematopoiesis
EMBO Molecular Medicine, 2015 Pluripotent stem cells (PSCs) such as embryonic stem cells or induced pluripotent stem cells represent a promising cell type to gain novel insights into human biology.
Mania Ackermann +3 more
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Frontiers in Physiology, 2017 The growth arrest-specific transcript 5 (GAS5) is a long noncoding RNA with low expression in multiple cancers. This meta-analysis aims to explore the association between GAS5 expression levels and cancer patients' prognosis.
Qunjun Gao +8 more
doaj +1 more source
Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
core +3 more sources
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer
Cells, 2021 Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms.
Macus Hao-Ran Bao, C. C. Wong
semanticscholar +1 more source
Nature Communications, 2019 WDFY2 is known as a tumour suppressor but its function is unclear. Here, the authors show that WDFY2 interacts with the v-SNARE VAMP3, leading to a suppression of the metalloprotease MT1-MMP secretion, suggesting that WDFY2 acts a tumour suppressor by ...
Marte Sneeggen +5 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2018 Hedgehog (Hh) pathway plays a key role in development from invertebrate to vertebrate. It is known to be involved in cell differentiation, polarity, proliferation, including the development of vertebrate limb and the establishment of flies’ body plan. To
Jaehyun Park +4 more
doaj +1 more source
DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]
, 2019 Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L +6 more
core +2 more sources
Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. [PDF]
, 2016 The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation.
Bakkali, Mohammed +9 more
core +2 more sources
The Journal of Cell Biology, 2003 ![Graphic][1] A frog oocyte germinal vesicle (center) can reprogram injected nuclei (white). Gurdon/ElsevierDolly, Polly, and friends proved that somatic cells are potentially totipotent, but the reprogramming that a somatic cell nucleus must undergo during cloning remains an error-
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Epigenetics of cellular reprogramming [PDF]
Current Opinion in Genetics & Development, 2013 Cells are constantly changing their state of equilibrium in response to internal and external stimuli. These changes in cell identity are driven by highly coordinated modulation of gene expression. This coordinated regulation is achieved in large part due to changes in the structure and composition of the chromatin, driven by epigenetic modulators ...
Krishnakumar, Raga, Blelloch, Robert H
openaire +5 more sources